{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:28:49Z","timestamp":1777350529119,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to analyze the available literature on using transcatheter aortic valve replacement (TAVR) for native aortic regurgitation (AR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical aortic valve replacement is the gold standard therapy for native AR. TAVR has emerged as an alternative approach in high\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, Scopus, and Cochrane CENTRAL were searched for reports of at least 5 patients undergoing TAVR for native AR. Outcomes included 30\u2010day mortality, myocardial infarction, stroke, major bleeding, postprocedural moderate to severe AR, and device success. Pooled estimates were calculated using a random\u2010effects model. Subgroup analysis and a meta\u2010regression were performed to study the effects of study level covariates on outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen studies (<jats:italic>n<\/jats:italic>\u2009=998 patients) were included. The rate of procedural success per Valve Academic Research Consortium \u2013 2 (VARC\u20102) criteria was 86.2% (78.8%\u201392.2%]. Thirty\u2010day mortality was 11.9% (9.4%\u201314.7%). Subgroup analysis showed the use of new generation valves was associated with lower 30\u2010day mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) and higher device success (<jats:italic>P<\/jats:italic>\u2009=\u20090.009) compared with early generation valves. There was no significant difference (<jats:italic>P<\/jats:italic>\u2009=\u20090.13) in the rate of 30\u2010day mortality between patients receiving purpose\u2010specific [8.2% (4.3%\u221213.1%); I2\u2009=\u20090%] and nonpurpose specific valves [13.0% (8.2%\u201318.6%); I2\u2009=\u200925%]. However, device success was higher (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) in patients who received purpose\u2010specific valves [96.3% (92.2%\u221298.9%); I2\u2009=\u20090%] compared with nonpurpose specific valves [84.4% (75%\u221291.9%); I2\u2009=46%].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAVR for native AR is associated with acceptable procedural success but increased early mortality. However, the safety and the efficacy of the procedure increased with newer valves.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27840","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T09:19:35Z","timestamp":1538299175000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Safety and efficacy of transcatheter aortic valve replacement for native aortic valve regurgitation: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-0995","authenticated-orcid":false,"given":"Wasiq Faraz","family":"Rawasia","sequence":"first","affiliation":[{"name":"Division of Cardiology, School of Medicine West Virginia University  Morgantown West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cook County Hospital  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Shariq","family":"Usman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dow Medical College Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq Jamal","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dow Medical College Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firzah Abdul","family":"Mujeeb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dow Medical College Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsin","family":"Chundrigar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Aga Khan University \u2013 Medical College  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Kalra","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Case Western Reserve University School of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio"},{"name":"Department of Medicine, Case Western Reserve University School of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, School of Medicine West Virginia University  Morgantown West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford J","family":"Kavinsky","sequence":"additional","affiliation":[{"name":"Division of Cardiology Rush University Medical Center  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":false,"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart &amp; Vascular Center, Harvard Medical School Harvard University  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)01064-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs455"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.08.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.488825"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.08.049"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000523"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs533"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v049.i05"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3511"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.07.037"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.04.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I6A127"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27370"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.01.138"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.05.014"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.08.022"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu155"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.03.004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.018"},{"issue":"5","key":"e_1_2_7_29_1","first-page":"229","article-title":"Expansion of the indication of transcatheter aortic valve implantation\u2010\u2010feasibility and outcome in \"off\u2010label\" patients compared with \"on\u2010label\" patients","volume":"27","author":"Frerker C","year":"2015","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.08.021"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.151"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.556"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx493.P5433"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.827"},{"key":"e_1_2_7_35_1","unstructured":"KoschykD ConradiL SchrimerJ DiemertP ReichenspurnerH BlankenbergS. Transcatheter aortic valve implantation for noncalcified pure aortic insufficiency\u2010initial results and follow\u2010up. Catheter Cardiovasc Interv 2014;83(suppl_1)."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.085"},{"issue":"14","key":"e_1_2_7_37_1","first-page":"1851","article-title":"Mortality and morbidity of aortic regurgitation in clinical practice","volume":"99","author":"Dujardin KS","year":"1999","journal-title":"A long\u2010term follow\u2010up study"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.536"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25975"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114705"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946533"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq339"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.011"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000503"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.27840","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T21:17:29Z","timestamp":1694726249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,30]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/ccd.27840"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27840","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,30]]},"assertion":[{"value":"2018-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}