{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:26:45Z","timestamp":1790098005990,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The impact of persistent left bundle\u2010branch block (pLBBB) on long\u2010term clinical outcome remains to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>New\u2010onset of pLBBB occurs frequently after transfemoral aortic valve implantation (TAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven hundred and seven consecutive patients who underwent TAVI were analyzed for baseline and procedural characteristics and clinical outcome in an up to 2\u2010year follow\u2010up. Patients were divided into either a group with pLBBB until hospital discharge or a group without LBBB. We performed propensity\u2010score matching and analyzed baseline characteristics, procedural data and clinical outcome of both groups. Patients received balloon\u2010expandable valves in 56.4%, mechanically expandable valves in 37.5%, and self\u2010expandable valves in 6.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A new\u2010onset, pLBBB was observed in 47.5% of patients after TAVI. The implantation of a mechanically expandable valve was associated with higher rate of pLBBB (54.2% vs. 20.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), whereas implantation of a balloon\u2010expandable valve was associated with lower incidence of pLBBB (39.8% vs. 73.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Deeper ventricular implantation at left\u2010coronary side led to higher rates of pLBBB (7.5\u2009\u00b1\u20092.5 vs. 6.7\u2009\u00b1\u20092.6\u2009mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The occurrence of pLBBB was associated with higher rates of permanent pacemaker implantation (40.9% vs. 15.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). By multivariate analysis, implantation of a mechanically expandable valve (Boston Scientific Lotus valve) was identified as independent predictor of occurrence of pLBBB (odds ratio 4.7, confidence interval 3.2\u20137.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the 2\u2010year follow\u2010up, there were no significant differences between \u201cpLBBB\u201d and \u201cno LBBB\u201d\u2014groups regarding mortality and rehospitalization due to heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The occurrence of pLBBB is associated with the choice of valve type and implantation depth and requires significantly higher rates of permanent pacemaker implantations. Importantly, there are no differences in the 2\u2010year follow\u2010up regarding mortality and rehospitalization due to heart failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27850","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T04:16:31Z","timestamp":1539058591000},"page":"538-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term clinical outcome of persistent left bundle branch block after transfemoral aortic valve implantation"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-0508","authenticated-orcid":false,"given":"Mirjam","family":"Ke\u00dfler","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University of Ulm  Ulm 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