{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:49:28Z","timestamp":1770371368178,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2016 YFC1100300"],"award-info":[{"award-number":["2016 YFC1100300"]}]},{"name":"Guangdong Science and Technology Department of China","award":["2015B070701008"],"award-info":[{"award-number":["2015B070701008"]}]},{"name":"Shenzhen Sanming medical project of China"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and feasibility of a modified poly(<jats:sc>l<\/jats:sc>\u2010lactic acid) (PLLA) atrial septal defect (ASD) occluder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five piglets were divided into two groups: an experimental group (<jats:italic>n<\/jats:italic>\u2009=\u200927) and a control group (<jats:italic>n<\/jats:italic>\u2009=\u200918). The experimental group underwent percutaneous implantation of a modified PLLA ASD device while the control group underwent percutaneous implantation of a widely used metal ASD device. X\u2010ray imaging, transthoracic echocardiography (TTE), electrocardiogram (ECG), histopathology and electron microscopic examination were performed at 7 days, 1, 3, 6, and 12 months after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven experimental piglets and 18 control piglets were all successfully implanted with modified biodegradable and metal ASD devices, respectively. While both devices exhibited very good occluding effects, the modified PLLA ASD devices were completely endothelialized at 3 months after implantation, and the endothelialization appeared to be more complete compared to the control group. Degradation of the PLLA devices was noted at 12 months follow\u2010up with no loss of integrity at the atrial septum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This animal model with implanting of the occluders was effective and not associated with complications. The modified PLLA ASD devices are more controllable and practical than our previous devices. The implanted devices demonstrated good endothelialization and degradability in short and moderate term follow\u2010up. Long\u2010term studies are now underway to further evaluate the biodegradability of this novel device.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27852","type":"journal-article","created":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T07:37:33Z","timestamp":1536478653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Study of biodegradable occluder of atrial septal defect in a porcine model"],"prefix":"10.1002","volume":"93","author":[{"given":"Bo\u2010Ning","family":"Li","sequence":"first","affiliation":[{"name":"Pediatric Cardiology Southern Medical University  Guangzhou China"},{"name":"Pediatric Cardiology Guangdong Cardiovascular Institute, Guangdong General Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Mei","family":"Xie","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Guangdong Cardiovascular Institute, Guangdong General 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