{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:53:50Z","timestamp":1792439630321,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"TherOx Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the randomized AMIHOT\u2010II trial, supersaturated oxygen [SSO<jats:sub>2<\/jats:sub>] delivered into the left anterior descending (LAD) artery via an indwelling intracoronary infusion catheter following primary percutaneous coronary intervention (PCI) significantly reduced infarct size in patients with anterior ST\u2010segment elevation myocardial infarction (STEMI) but resulted in a numerically higher incidence of safety events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The IC\u2010HOT study evaluated the safety of SSO<jats:sub>2<\/jats:sub> therapy selectively delivered to the left main coronary artery (LMCA) for 60\u2009minutes after PCI in patients with anterior STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SSO<jats:sub>2<\/jats:sub> therapy was administered to the LMCA after stent implantation in 100 patients with anterior STEMI and proximal or mid\u2010LAD occlusion presenting within 6\u2009hours of symptom onset. The primary endpoint was the 30\u2010day composite rate of net adverse clinical events (NACE) (death, reinfarction, clinically driven target vessel revascularization, stent thrombosis, severe heart failure, or TIMI major\/minor bleeding) compared against an objective performance goal of 10.7%. Cardiac magnetic resonance imaging was performed at 4 and 30\u2009days to assess infarct size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SSO<jats:sub>2<\/jats:sub> delivery was successful in 98% of patients. NACE at 30\u2009days occurred 7.1% of patients (meeting the primary safety endpoint of the study); there were no deaths, only one stent thrombosis and one case of severe heart failure. Median [interquartile range] infarct size was 24.1% [14.4%, 31.6%] at 4 days and 19.4% [8.8%, 28.9%] at 30\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Following primary PCI in acute anterior STEMI, infusion of SSO<jats:sub>2<\/jats:sub> via the LMCA was feasible and was associated with a favorable early safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27905","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T22:40:28Z","timestamp":1538174428000},"page":"882-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of intracoronary hyperoxemic oxygen therapy in acute anterior myocardial infarction: The IC\u2010HOT study"],"prefix":"10.1002","volume":"93","author":[{"given":"Shukri W.","family":"David","sequence":"first","affiliation":[{"name":"Providence\u2010Providence Park Hospital  Southfield Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubair A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Providence\u2010Providence Park Hospital  Southfield Michigan"},{"name":"North Alabama Medical Center  Florence Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nainesh C.","family":"Patel","sequence":"additional","affiliation":[{"name":"Lehigh Valley Hospital  Allentown Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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