{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:48:46Z","timestamp":1758476926869,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To identify risk factors for composite outcome of mortality, stroke or myocardial infarction in patients with severe carotid stenosis undergoing staged carotid artery stenting (CAS) with subsequent cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In this prospective observational study, we enrolled 643 consecutive patients with both symptomatic (i.e., with history of stroke) and asymptomatic severe carotid artery disease, who required cardiac surgery. Generally, cardiac surgery was planned 30 days after the CAS procedure. The composite outcome consisted of death, stroke and myocardial infarction.<\/jats:p><jats:p>The composite outcome rate was 26.3% at 5 years and 47% at 8 years after CAS. Age \u2265 80 years (hazard ratio [HR] = 1.89; 95%CI, 1.18\u20133.03; <jats:italic>P<\/jats:italic> = 0.008), history of stroke (HR = 1.66, 1.16\u20132.37; <jats:italic>P<\/jats:italic> = 0.006), chronic obstructive pulmonary disease (HR = 1.86; 1.07\u20133.24; <jats:italic>P<\/jats:italic> = 0.03) and kidney disease (HR = 1.83, 1.11\u20133.04; <jats:italic>P<\/jats:italic> = 0.02) were independent risk factors for the composite outcome during long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study with staged CAS followed by cardiac surgery, we confirm previously reported event\u2010free survival rates and identify several risk factors for the composite outcome. Future studies are needed to confirm the importance of the identified risk factors and to assess their predictive ability.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27947","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T13:19:02Z","timestamp":1541769542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term results of carotid stenting and risk factors in patients with severe carotid artery stenosis undergoing subsequent cardiac surgery"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-4100","authenticated-orcid":false,"given":"Najibullah","family":"Habib","sequence":"first","affiliation":[{"name":"Department of Cardiology Sint Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakhtawar K.","family":"Mahmoodi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sint Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten J.","family":"Suttorp","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sint Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes C.","family":"Kelder","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sint Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma C.","family":"Tromp","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Sint Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uday","family":"Sonker","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and 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