{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:38:25Z","timestamp":1761863905013,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the in vivo feasibility of aortography with one accurately timed diastolic low\u2010volume contrast injection for quantitative assessment of aortic regurgitation (AR) post transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>With the rise of a minimalistic approach for TAVR, aortography (re)emerges as a pragmatic tool for AR assessment. In a mock circulation system, we have validated the accuracy of a single diastolic injection triggered by electrocardiogram (ECG) with low\u2010contrast volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two\u2010phase experiment: first, a series of aortograms were performed in a porcine model, with 8 mL of contrast using the synchronized (SYNC) and the conventional non\u2010synchronized (NS) injections. In a second phase, we developed a model of AR by inserting partially unsheathed Wallstents of 6\u201310 mm of diameter across the pig's aortic valve, performing SYNC injections with 8 mL of contrast and NS injections with 8 mL and 15\u2009mL (rate: 20\u2009mL\/sec). Respective accuracies of SYNC vs. NS were assessed using Passing\u2010Bablock regression. An angiography core laboratory performed quantitative AR assessment with videodensitometry (VD\u2010AR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SYNC injections produced higher opacification of the aortic root compared with NS injections (<jats:italic>P<\/jats:italic>\u2009=\u20090.04 for density). In the second phase, a regression line for predicting VD\u2010AR based on the SYNC injection resulted in a lower intercept and a slope closer to the line of identity (y\u2009=\u200911.9\u2009+\u20090.79x, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, r<jats:sup>2<\/jats:sup>\u2009=\u20090.94) with the NS\u20108 mL than with the NS\u201015\u2009mL injection (y\u2009=\u200926.5\u2009+\u20090.55x, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, r<jats:sup>2<\/jats:sup>\u2009=\u20090.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Synchronized diastolic injection with low contrast volume produced denser images in the aortic root and more accurate than the conventional injection; thus, may be an appealing alternative for assessment of AR post TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27972","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T15:47:13Z","timestamp":1542296833000},"page":"963-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Feasibility study of a synchronized diastolic injection with low contrast volume for proper quantitative assessment of aortic regurgitation in porcine models"],"prefix":"10.1002","volume":"93","author":[{"given":"Rodrigo","family":"Modolo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Internal Medicine Cardiology Division, University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Thoraxcenter Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-1185","authenticated-orcid":false,"given":"Chun Chin","family":"Chang","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Thoraxcenter Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike","family":"te Lintel Hekkert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Experimental Cardiology Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Math","family":"van Sloun","sequence":"additional","affiliation":[{"name":"ACIST Medical Systems  Eden Prairie Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Suchecki","sequence":"additional","affiliation":[{"name":"ACIST Medical Systems  Eden Prairie Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Aben","sequence":"additional","affiliation":[{"name":"Pie Medical Imaging  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama I.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Thoraxcenter Erasmus University Medical Center  Rotterdam The Netherlands"},{"name":"Cardialysis Clinical Trials Management and Core Laboratories  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Thoraxcenter Erasmus University Medical Center  Rotterdam The Netherlands"},{"name":"Cardialysis 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