{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:26:22Z","timestamp":1762507582669,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hanyu Medical Technology, Shanghai, China"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>The present study was performed to evaluate the feasibility and safety of the ValveClamp system for transcatheter edge\u2010to\u2010edge mitral valve repair in a porcine model.<\/jats:p><\/jats:sec>Background<\/jats:title>The ValveClamp system is a novel, transapically delivered edge\u2010to\u2010edge mitral valve repair system designed for ease of operation.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirteen young adult swine were enrolled in the study. The procedure was performed via the transapical approach under epicardial echocardiography guidance.<\/jats:p><\/jats:sec>Results<\/jats:title>The acute procedure success rate was 92.3% (12\/13). The catheter manipulation time was just 18.5\u2009\u00b1 8.2 min. Four pigs were explanted on the 14th day after the procedure. One pig died at the 20th day because of pneumonia. The other eight pigs lived to the study endpoint (140\u2009days). No pig had severe mitral valve dysfunction. The gross observation showed that the clamp device was securely attached and created a double\u2010orifice mitral valve in all pigs except the failed one. In the eight pigs living to the endpoint, the clamp device was noted to be completely endothelialized. None of the 13 pigs developed infective endocarditis, thrombosis, thromboembolism, or valve impairment. In two pigs for which mitral regurgitation (MR) was created, the degree of MR was reduced from severe to trace after the device implantation.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>It was feasible and safe to use ValveClamp to perform a catheter\u2010mediated edge\u2010to\u2010edge mitral valve repair in a porcine model. This system is potentially applicable as a novel user\u2010friendly system for the treatment of MR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27976","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T07:03:43Z","timestamp":1542351823000},"page":"1354-1360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A novel user\u2010friendly transcatheter edge\u2010to\u2010edge mitral valve repair device in a porcine model"],"prefix":"10.1002","volume":"93","author":[{"given":"Wenzhi","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuizhen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Jilaihawi","sequence":"additional","affiliation":[{"name":"NYU Langone Health New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, National Centre for Cardiovascular Disease Fuwai Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9926-5708","authenticated-orcid":false,"given":"Daxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Institute of 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