{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:41:11Z","timestamp":1773056471961,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the impact of the introduction of the next generation self\u2010expanding (SE) and balloon\u2010expandable (BE) transcatheter heart valves (THVs) on the incidence of prosthesis\u2013patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>PPM is a risk factor for accelerated degeneration of bioprosthetic aortic valves. Data on PPM after TAVR are derived mainly from studies of older generation THVs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PPM was assessed at 30\u2009days post\u2010TAVR with the older generation (Medtronic CoreValve, n\u2009=\u2009120 and Edwards Sapien XT, n\u2009=\u2009121) and the next generation THVs (Medtronic Evolut R\/Pro, n\u2009=\u2009136 and Edwards Sapien 3, n\u2009=\u2009363).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of any and severe PPM was 15.1% and 0.0% for the older generation THVs, and 42.8% and 12.1% for the next generation THVs. The incidence of moderate and severe PPM was 23.3% and 3.5% in patients who received an Evolut R\/Pro vs. 33.1% and 14.7% in those who received a Sapien 3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). On multivariable analysis, TAVR with the Sapien 3 THV was not associated with PPM, while left ventricular ejection fraction (0.97 [0.95\u20130.99], <jats:italic>P<\/jats:italic>\u2009=\u20090.002), history of myocardial infarction (2.09 [1.00\u20134.34], <jats:italic>P<\/jats:italic>\u2009=\u20090.049), annulus maximum diameter (0.84 [0.77\u20130.92], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and THV oversizing (0.90 [0.87\u20130.94], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were independently associated with PPM. In Sapien 3, the risk of any and severe PPM was higher in those with no oversizing (odds ratio: 3.25 [1.23\u20138.53], <jats:italic>P<\/jats:italic>\u2009=\u20090.017 and 5.79[2.33\u201314.36], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of PPM in contemporary TAVR is significant, especially with the next generation BE THV without adequate oversizing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27977","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T09:32:14Z","timestamp":1542965534000},"page":"971-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Impact of prosthesis\u2010iteration evolution and sizing practice on the incidence of prosthesis\u2013patient mismatch after transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-8749","authenticated-orcid":false,"given":"Mohammad","family":"Abdelghani","sequence":"first","affiliation":[{"name":"The Heart Center, Segeberger Kliniken  Bad Segeberg Germany"},{"name":"Cardiology Department, The Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-6789","authenticated-orcid":false,"given":"Abdelhakim","family":"Allali","sequence":"additional","affiliation":[{"name":"The Heart Center, Segeberger Kliniken  Bad Segeberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatinderjit","family":"Kaur","sequence":"additional","affiliation":[{"name":"The Heart Center, Segeberger Kliniken  Bad Segeberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayyan","family":"Hemetsberger","sequence":"additional","affiliation":[{"name":"The Heart Center, Segeberger Kliniken  Bad Segeberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8750-5567","authenticated-orcid":false,"given":"Julinda","family":"Mehilli","sequence":"additional","affiliation":[{"name":"Munich University Center Ludwig\u2010Maximilians University  Munich Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz\u2010Josef","family":"Neumann","sequence":"additional","affiliation":[{"name":"Heart Center Freiburg\u2010Bad Krozingen  Bad Krozingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Frerker","sequence":"additional","affiliation":[{"name":"Cardiology Department 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