{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:01:48Z","timestamp":1768784508516,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report mid\u2010term results after MitraClip repair, according to mitral regurgitation (MR) mechanism, in a real\u2010world single\u2010center experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Mid\u2010term outcomes of percutaneous edge\u2010to\u2010edge mitral repair in the real world are still limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the follow\u2010up results of patients treated with MitraClip at a single high\u2010volume mitral center from 2008 to 2016. All patients underwent Heart\u2010Team discussion, prospective data collection and enrolment in a dedicated outpatient clinic. Functional (FMR, n\u2009=\u2009242, 68.6%) and degenerative (DMR, n\u2009=\u200997, 27.5%) MR patients were separately analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>5\u2010Year survival was 53.5\u2009\u00b1\u20094.5% in FMR vs 57.1\u2009\u00b1\u20097.5% in DMR (<jats:italic>P<\/jats:italic>\u2009=\u20090.087). Reduced survival was strongly associated with worse left ventricle remodeling (ESV HR 1.01, CI 1.01\u20131.02, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in FMR, and with worse symptoms (New York Heart Association IV HR 6.72, CI 1.78\u201325.45, <jats:italic>P<\/jats:italic>\u2009=\u20090.005) in DMR. 5\u2010Year cumulative incidence function for MR\u2009\u2265\u20093 was 23.7\u2009\u00b1\u20093.4% in FMR vs 27.9\u2009\u00b1\u20095.9% in DMR (<jats:italic>P<\/jats:italic>\u2009=\u20090.39), being associated with residual MR\u2009=\u20092 both in FMR (HR 4.67, CI 2.49\u20138.74, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and DMR (HR 7.15, CI 2.72\u201318.75, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). At 5\u2010year, patients in NYHA class I\u2010II increased from 17.9% to 45.3% in FMR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and from 33.3% to 51.3% in DMR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this single\u2010center real\u2010world experience, 5\u2010year after MitraClip, half of the patients were alive and 3\/4 were free from MR, both in FMR and DMR. Symptoms benefit was sustained in both groups. Advanced ventricular remodeling, advanced symptoms, and suboptimal MR reduction were associated with worse results. Refined patient selection, improved efficacy and more data will be all required to improve long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28029","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T07:33:31Z","timestamp":1545982411000},"page":"427-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mid\u2010term outcomes (up to 5 years) of percutaneous edge\u2010to\u2010edge mitral repair in the real\u2010world according to regurgitation mechanism: A single\u2010center experience"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-3739","authenticated-orcid":false,"given":"Nicola","family":"Buzzatti","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery San Raffaele Scientific Institute  Milan 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