{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:45:23Z","timestamp":1772937923545,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1114408"],"award-info":[{"award-number":["1114408"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["101107"],"award-info":[{"award-number":["101107"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the clinical efficacy of renal artery denervation (RAD) in our center and to compare the efficacy of two different radiofrequency (RF) systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Several systems are available for RF renal denervation. Whether there is a difference in clinical efficacy among various systems remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Renal artery denervation was performed on 43 patients with resistant hypertension using either the single electrode Symplicity Flex (n\u2009=\u200920) or the multi\u2010electrode EnligHTN system (n\u2009=\u200923). Median post\u2010procedural follow\u2010up was 32.93\u2009months. The primary outcome was post\u2010procedural change in office blood pressure (BP) within 1 year (short\u2010term follow\u2010up). Secondary outcomes were change in office BP between 1 and 4 years (long\u2010term follow\u2010up) and the difference in office BP reduction between the two systems at each follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the total cohort, mean baseline office BP (systolic\/diastolic) was 174\/94\u2009mmHg. At follow\u2010up, mean changes in office BP from baseline were \u221219.70\/\u221211.86\u2009mmHg (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and \u221221.90\/\u221213.94\u2009mmHg (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) for short\u2010term and long\u2010term follow\u2010up, respectively. The differences in office BP reduction between Symplicity and EnligHTN groups were 8.96\/1.23\u2009mmHg (<jats:italic>P<\/jats:italic> =\u20090.42 for systolic BP, <jats:italic>P<\/jats:italic> =\u20090.83 for diastolic BP) and 9.56\/7.68\u2009mmHg (<jats:italic>P<\/jats:italic> =\u20090.14 for systolic BP, <jats:italic>P<\/jats:italic> =\u20090.07 for diastolic BP) for short\u2010term and long\u2010term follow\u2010up, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our cohort, there was a clinically significant office BP reduction after RAD, which persisted up to 4 years. No significant difference in office BP reduction between the two systems was found.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28038","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T14:34:49Z","timestamp":1544798089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of two different radiofrequency ablation systems for renal artery denervation: Evaluation of short\u2010term and long\u2010term follow up"],"prefix":"10.1002","volume":"93","author":[{"given":"Sara I.","family":"Al Raisi","sequence":"first","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Pouliopoulos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"King","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Byth","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"},{"name":"Research and Educational Network, Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Swinnen","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aravinda","family":"Thiagalingam","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-5046","authenticated-orcid":false,"given":"Pramesh","family":"Kovoor","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60566-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62039-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62192-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402670"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu441"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.06.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.09.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.130880"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht197"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.069"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I2A46"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04176"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I6A112"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.059"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00278"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.04.057"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04336"},{"key":"e_1_2_9_19_1","first-page":"93","article-title":"Reduced blood pressure\u2010lowering effect of catheter\u2010based renal denervation in patients with isolated systolic hypertension: Data from SYMPLICITY HTN\u20103 and the global SYMPLICITY registry","volume":"38","author":"Mahfoud F","year":"2017","journal-title":"Eur Heart J"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12I5A110"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005879"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32281-X"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30951-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31082-1"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:52:19Z","timestamp":1694670739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,14]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,2,15]]}},"alternative-id":["10.1002\/ccd.28038"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28038","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,14]]},"assertion":[{"value":"2018-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}