{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:35:53Z","timestamp":1767897353824,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study were to compare short\u2010 and intermediate\u2010term clinical outcomes, procedural complications, TAVR prosthesis hemodynamics, and paravalvular leak (PVL) in stentless and stented groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Valve\u2010in\u2010valve (ViV) transcatheter aortic valve replacement (TAVR) is an alternative to surgical redo for bioprosthetic valve failure. There have been limited data on ViV in stentless surgical valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 40 patients who underwent ViV TAVR in prior surgical bioprosthetic valves at Wake Forest Baptist Medical Center from October 2014 to September 2017. Eighty percent (32\/40) ViV TAVRs were in stentless, while 20% (8\/40) were in stented bioprosthetic valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary mode of bioprosthetic valve failure for ViV implantation in the stentless group was aortic insufficiency (78%, 25\/32), while in the stented group was aortic stenosis (75%, 6\/8). The ViV procedure success was 96.9% (31\/32) in stentless group and 100% in stented group (8\/8). There were no significant differences in all\u2010cause mortality at 30\u2009days between stentless and stented groups (6.9%, 2\/31 versus 0%, 0\/8, <jats:italic>P<\/jats:italic>\u2009=\u20090.33) and at 1 year (0%, 0\/25 versus 0%, 0\/5). In the stentless group, 34.4% (11\/32) required a second valve compared to the stented group of 0% (0\/8). There was a significant difference in the mean aortic gradient at 30\u2010day follow\u2010up (12.33\u2009\u00b1\u20096.33\u2009mmHg and 22.63\u2009\u00b1\u20098.45\u2009mmHg in stentless and stented groups, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and at 6\u2010month follow\u2010up (9.75\u2009\u00b1\u20095.07\u2009mmHg and 24.00\u2009\u00b1\u200911.28\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ViV in the stentless bioprosthetic aortic valve has excellent procedural success and intermediate\u2010term results. Our study shows promising data that may support the application of TAVR in stentless surgical aortic valve. However, further and larger studies need to further validate our single center's experience.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28039","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T09:45:52Z","timestamp":1545903952000},"page":"1106-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A comparison of valve\u2010in\u2010valve transcatheter aortic valve replacement in failed stentless versus stented surgical bioprosthetic aortic valves"],"prefix":"10.1002","volume":"93","author":[{"given":"Charles H.","family":"Choi","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine Wake Forest University Baptist Medical Center, Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine Wake Forest University Baptist Medical Center, Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Malaver","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine Wake Forest University Baptist Medical Center, Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Kon","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Wake Forest University Baptist Medical Center, Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward H.","family":"Kincaid","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Wake Forest University Baptist Medical Center, Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay K.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine Wake Forest University Baptist Medical Center, Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Applegate","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine Wake Forest University Baptist Medical Center, Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6348-0732","authenticated-orcid":false,"given":"David X. 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