{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:04:51Z","timestamp":1769162691045,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polymer\u2010free amphilimus\u2010eluting stents (PF\u2010AES) represent a novel elution\u2010technology in coronary stenting. We aimed to assess 1\u2010year clinical outcomes of PF\u2010AES as compared to latest\u2010generation permanent polymer zotarolimus\u2010eluting stents (PP\u2010ZES) in a real\u2010world all\u2010comers setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective registry of patients treated with either PF\u2010AES or PP\u2010ZES between 2014 and 2016 was conducted. The primary outcome was defined as major adverse cardiac and cerebrovascular events (MACCE), and the secondary outcome was defined as target\u2010lesion failure (TLF) at 1 year. To account for measured confounders, a propensity\u2010score adjusted Cox proportional\u2010hazard model was built to evaluate clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 734 consecutive patients with 1,269 DES implantations were enrolled. The population was characterized by 28% diabetes, 24% ST\u2010segment elevation myocardial infarction, and a high number of complex lesions (69%). The rate of MACCE was 11.5% for PF\u2010AES and 13.6% for PP\u2010ZES, p<jats:sub>log\u2010rank<\/jats:sub>\u2009=\u20090.11. TLF was numerically lower in PF\u2010AES as compared to PP\u2010ZES (5.4 vs. 6.1%, p<jats:sub>log\u2010rank<\/jats:sub>\u2009=\u20090.68). After propensity\u2010score adjustment, PF\u2010AES showed a trend toward a lower rate of MACCE and a favorable rate of TLF as compared to PP\u2010ZES (HR 0.70; 95%CI 0.45 to 1.10, <jats:italic>P<\/jats:italic>\u2009=\u20090.12; and HR 0.88; 95%CI 0.47 to 1.65, <jats:italic>P<\/jats:italic>\u2009=\u20090.68, respectively). Rates of definite ST were low (0.8 vs. 0.3%, p<jats:sub>log\u2010rank<\/jats:sub>\u2009=\u20090.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that implantation of PF\u2010AES was safe and effective in real\u2010world patients, with low\u2010rates of MACCE and TLF at 1 year. Our data needs to be confirmed by a large trial to evaluate the clinical outcomes of this novel polymer\u2010free, eluting\u2010technology used in PF\u2010AES.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28041","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T06:14:01Z","timestamp":1546496041000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["One\u2010year clinical outcomes of patients treated with polymer\u2010free amphilimus\u2010eluting stents or zotarolimus\u2010eluting stents: A propensity\u2010score adjusted analysis"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-7959","authenticated-orcid":false,"given":"Rik","family":"Rozemeijer","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Centre Utrecht  Utrecht The 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Cardiology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia Z.","family":"Rittersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan O.","family":"Kraaijeveld","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"Doevendans","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Centre Utrecht  Utrecht The Netherlands"},{"name":"Netherlands Heart Institute  Utrecht The Netherlands"},{"name":"Central Military Hospital  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"Voskuil","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter R.","family":"Stella","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Centre Utrecht  Utrecht The 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