{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:20:12Z","timestamp":1790112012646,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the efficacy and safety of drug\u2010eluting stents (DESs) and bare metal stents (BMSs) when used with short or tailored dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>DES have been shown to reduce target lesion revascularization (TLR) as well as stent thrombosis (ST) compared to BMS in patients undergoing percutaneous coronary intervention (PCI). However, patients at HBR continue to receive BMS given the fear of bleeding or ST from premature discontinuation of DAPT in patients receiving DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a meta\u2010analysis of randomized controlled trials by performing systematic search for studies comparing DES with BMS in HBR patients using PUBMED, MEDLINE, and Cochrane Central, reported until March 1, 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three randomized controlled studies met the inclusion criteria with total of 4,460 patients; 50% received DES. Major adverse cardiovascular event (MACE); composite of death, myocardial infarction (MI), and TLR, at 1\u2009year was significantly lower (RR\u2009=\u20090.63, 95% CI 0.50\u20130.80) in DES group compared to BMS. This difference was primarily driven by lower TLR (RR\u2009=\u20090.46, 95% CI 0.35\u20130.61) in DES group. Definite or probable ST (RR\u2009=\u20090.59, 95% CI\u2009=\u20090.32\u20131.08) and major (RR\u2009=\u20090.94, 95% CI\u2009=\u20090.74\u20131.20) bleeding were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DES was associated with lower MACE without increased risk of bleeding or ST compared to BMS when used with short or tailored DAPT in patients with HBR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28045","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T10:24:33Z","timestamp":1545819873000},"page":"98-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Meta\u2010analysis of drug eluting stents compared with bare metal stents in high bleeding risk patients undergoing percutaneous coronary interventions"],"prefix":"10.1002","volume":"94","author":[{"given":"Saroj","family":"Neupane","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Henry Ford Hospital  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owais","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine St John Hospital and Medical Center  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushruth","family":"Edla","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine St John Hospital and Medical Center  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemindermeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Cardiovascular Fellowship Program Mercy\u2010Health St Vincent Medical Center  Toledo Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Othman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine St John Hospital and Medical Center  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bossone","sequence":"additional","affiliation":[{"name":"Cava de' Tirreni and Amalfi Coast Hospital University of Salerno  Amalfi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine St John Hospital and Medical Center  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard S.","family":"Rosman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine St John Hospital and Medical Center  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Eggebrecht","sequence":"additional","affiliation":[{"name":"Cardioangiological Center Bethanien (CCB) and AGAPLESION Bethanien Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607991"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.053"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.06.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00548-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.049"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw215"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.053"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503943"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32713-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.11.015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.021"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.895342"},{"key":"e_1_2_7_17_1","unstructured":"KrukoffMW. 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