{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T10:11:56Z","timestamp":1777198316329,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T00:00:00Z","timestamp":1549670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to compare the coronary angioscopic appearance of neointimal coverage (NIC) over durable\u2010polymer everolimus\u2010eluting stents (XIENCE\u2010EES) and bioresorbable\u2010polymer everolimus\u2010eluting stents (SYNERGY\u2010EES) 1 year after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>XIENCE\u2010EES and SYNERGY\u2010EES have been developed to prevent delayed arterial healing associated with first generation drug\u2010eluting stents. However, the process of arterial healing after XIENCE\u2010EES and SYNERGY\u2010EES implantation has not been clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent implantation of XIENCE\u2010EES (n\u2009=\u200920) or SYNERGY\u2010EES (n\u2009=\u200920) were enrolled in this study. Coronary angiography and coronary angioscopy were performed 12\u2009\u00b1\u20091 months after stent implantation. The NIC over the stent was classified into four grades: grade 0, stent struts fully exposed; grade 1, stent struts bulging into the lumen and, still visible; grade 2, stent struts embedded in neointima but still visible; and grade 3, stent struts fully embedded and invisible. Stents exhibiting more than one NIC grade was defined as heterogeneous. Moreover, presence of thrombi was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of dominant NIC grade (XIENCE\u2010EES: grade 0, 0%; grade 1, 25%; grade 2, 50%; grade 3, 25%; SYNERGY\u2010EES: grade 0, 0%; grade 1, 5%; grade 2, 15%; grade 3, 80%; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and NIC heterogeneity was significantly different (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). Thrombi were more frequent in XIENCE\u2010EES than in SYNERGY\u2010EES (40 versus 10%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with XIENCE\u2010EES, SYNERGY\u2010EES were well covered by neointima and accompanied by fewer thrombi. These findings implied arterial healing of SYNERGY\u2010EES was better than that of XIENCE\u2010EES.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28095","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T13:25:00Z","timestamp":1549718700000},"page":"204-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of neointimal coverage between durable\u2010polymer everolimus\u2010eluting stents and bioresorbable\u2010polymer everolimus\u2010eluting stents 1 year after implantation using high\u2010resolution coronary angioscopy"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4835-0993","authenticated-orcid":false,"given":"Yuhei","family":"Nojima","sequence":"first","affiliation":[{"name":"Department of Cardiology Nishinomiya Municipal Central Hospital  Nishinomiya Hyogo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Nanto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nishinomiya Municipal Central Hospital  Nishinomiya Hyogo 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