{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:42:07Z","timestamp":1765827727473,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to assess the association of left ventricular end\u2010diastolic pressure (LVEDP) with myocardial salvage and long\u2010term mortality in ST\u2010segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The association of LVEDP with myocardial salvage or long\u2010term mortality in patients with STEMI has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 1,312 patients with STEMI undergoing primary PCI between 2002 and 2007. LVEDP was measured at the time of intervention. Patients were divided into three groups: a group with LVEDP in the 1st tertile (LVEDP, 4\u201319\u2009mmHg; n\u2009=\u2009496), a group with LVEDP in the 2nd tertile (LVEDP &gt;19\u201324\u2009mmHg; n\u2009=\u2009410) and a group with LVEDP in the 3rd tertile (LVEDP &gt;24\u201345\u2009mmHg; n\u2009=\u2009406). The primary outcome was 8\u2010year cardiac mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary outcome (cardiac deaths) occurred in 114 patients. Deaths occurred in 26 (7.9%), 36 (11.5%), and 52 (16.4%) patients with LVEDP in the 1st to 3rd tertiles, respectively (adjusted hazard ratio\u2009=\u20091.18, 95% confidence interval 1.02\u20131.36, <jats:italic>P<\/jats:italic>\u2009=\u20090.022, for 5 mmHg increment in the LVEDP values). LVEDP correlated with the extent of myocardial ischemia (R\u2009=\u20090.351; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In patients with LVEDP in the 1st to 3rd tertiles, the salvage index (proportion of initial area at risk salvaged) was 0.53 [0.27\u20130.84], 0.53 [0.28\u20130.80], and 0.43 [0.18\u20130.75], respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.012). After adjustment, LVEDP correlated inversely with myocardial salvage (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with STEMI, elevated LVEDP correlated with the extent of myocardial ischemia, reduced myocardial salvage and increased risk of 8\u2010year cardiac mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28098","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T09:57:32Z","timestamp":1548410252000},"page":"901-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship of left ventricular end\u2010diastolic pressure with extent of myocardial ischemia, myocardial salvage and long\u2010term outcome in patients with ST\u2010segment elevation myocardial infarction"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-055X","authenticated-orcid":false,"given":"Gjin","family":"Ndrepepa","sequence":"first","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Cassese","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desard","family":"Hashorva","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8091-4552","authenticated-orcid":false,"given":"Sebastian","family":"Kufner","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-2819","authenticated-orcid":false,"given":"Erion","family":"Xhepa","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endri","family":"Hasimi","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Fusaro","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[{"name":"1. Medizinische Klinik, Klinikum rechts der Isar Technische Universit\u00e4t  Munich Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) partner site Munich Heart Alliance  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) partner site Munich Heart Alliance  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t  Munich Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) partner site Munich Heart Alliance  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199805)44:1<70::AID-CCD17>3.0.CO;2-T"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106849"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.45.1.11"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03085962"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:THRO.0000040486.10549.f6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.06.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.08.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-017-9776-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.100818"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.054"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121437"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008103430602"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2007.06624.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.15.1972"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27625"},{"key":"e_1_2_8_18_1","first-page":"725","article-title":"Prognostic value of myocardial salvage achieved by reperfusion therapy in patients with acute myocardial infarction","volume":"45","author":"Ndrepepa G","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.034"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-017-1080-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.002790"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.03.073"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.28098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:05:54Z","timestamp":1694163954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/ccd.28098"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28098","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2019,1,25]]},"assertion":[{"value":"2018-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}