{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:08:56Z","timestamp":1788480536447,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate efficacy, safety and feasibility of targeted intracoronary injection using pro\u2010urokinase combined with anisodamine (TCA) versus thrombus aspiration (TA) in ST\u2010elevation myocardial infarction (STEMI) patients with high thrombus loads.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The best method of avoiding thrombus detachment and stroke in PCI patients with high thrombus loads has not yet been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>STEMI patients receiving coronary artery angiography or percutaneous coronary intervention (CAG\/PCI) with thrombus grade\u2009\u2265\u20093 from January 1, 2017 to June 30, 2018 were randomly assigned to targeted intracoronary thrombolysis (pro\u2010urokinase and anisodamine via catheter (TCA) group), or the TA group which followed the standard thrombus aspiration procedure. Parameters compared included thrombus grade, index of microcirculatory resistance (IMR), postoperative myocardial SPECT, thrombosis in myocardial infarction (TIMI) scores including flow grade, corrected TIMI frame counts (CTFCs), and TIMI myocardial perfusion grade (TMPG). Adverse events were followed up within 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine patients were finally enrolled. In primary CAG\/PCI, the TCA group had higher percentages of TIMI 3 flow and lower IMR values compared with the TA group. The ratio of TMPG 3 grade in the TCA group was higher in repeat CAG, and the perfusion descending area (PDA) presented by SPECT was lower than in the TA group. No significant difference was seen in major adverse coronary events (MACEs) or bleeding events at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TCA appears to be effective, safe, and feasible for repatency and reduction of high thrombus burden in primary PCI and may protect myocardial microcirculation with improved outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28112","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T07:13:31Z","timestamp":1550474011000},"page":"839-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of myocardial microcirculatory perfusion after catheter\u2010administered intracoronary thrombolysis with anisodamine versus standard thrombus aspiration in patients with ST\u2010elevation myocardial infarction"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-4282","authenticated-orcid":false,"given":"Yang","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Shun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Zhen","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Fa","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Hospital of Hebei Medical University  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