{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:30:57Z","timestamp":1779003057575,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify prevalence\/impact of previous implantation of cardiac electronic devices (CEDs), such as cardioverter defibrillator (ICD) and cardiac resynchronization (CRT), in a group of MitraClip (MC) candidates with LVEF\u2009&lt;\u200930%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>MC therapy is nowadays often considered in patients with depressed left ventricular ejection fraction (LVEF%) and symptomatic severe secondary MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the German Transcatheter Mitral Valve Interventions (TRAMIs) registry were analyzed. Patients with pre\u2010procedural LVEF\u2009&lt;30% were selected and divided according to the presence of CEDs. Pre\u2010procedural, peri\u2010procedural, and 1\u2010year follow\u2010up data were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 689 MC patients, 235 had LVEF&lt;30%. Of these, 23% (54\/235) had CRT, 36.6% (86\/235) ICD, and 40.4% (95\/235) had no CEDs. Risk profile was similar (median STS score CRT 6.0 (IQR: 3.0\u201312.0); ICD 7.0 (IQR: 4.0\u201312.0); No\u2010CED 6.5 (IQR: 2.0\u201310.0); <jats:italic>p<\/jats:italic>\u2009=\u20090.8). No procedural mortality was observed and hospital mortality was 5.6% in CRT, 2.3% in ICD, and 3.2% in No\u2010CED (<jats:italic>p<\/jats:italic>\u2009=\u20090.5). At discharge, severe MV regurgitation was reported in 3.8% of CRT, 3.7% of ICD, and 1.1% of No\u2010CED (<jats:italic>p<\/jats:italic>\u2009=\u20090.9). One year estimated survival (CRT 75.7%; ICD 75.8%; No\u2010CED 78%; <jats:italic>p<\/jats:italic>\u2009=\u20090.94) and freedom from MACCE (CRT 73.6%; ICD 75.8%; No\u2010CED 74.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.88) were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A third of patients have been already submitted to CEDs implantation at time of referral for MC therapy and 40% of those with severely depressed LVEF% arrive to MC therapy before ICD\/CRT implantation. The presence of CED does not impair acute MC therapy success. Mid\u2010term follow\u2010up outcomes are similar in patients with and without CEDs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28127","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T11:39:09Z","timestamp":1550749149000},"page":"755-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Percutaneous treatment of mitral regurgitation in patients with impaired ventricular function: Impact of intracardiac electronic devices (from the German Transcatheter Mitral Valve Interventions Registry)"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-4521","authenticated-orcid":false,"given":"Giuseppe","family":"D'Ancona","sequence":"first","affiliation":[{"name":"Deapartment of Cardiology and Clinical Cardiovascular Research Unit, Vivantes Klinikum im Friedrichshain und Am Urban, Berlin Germany and Rostock University Medical Center  Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Deapartment of Cardiology and Clinical Cardiovascular Research Unit, Vivantes Klinikum im Friedrichshain und Am Urban, Berlin Germany and Rostock University Medical Center  Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schillinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herzzentrum, Georg\u2010August\u2010Universit\u00e4t G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Department of Cardiology, Helios Albert\u2010Schweitzer\u2010Klinik Northeim  Northeim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taoufik","family":"Ouarrak","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herzzentrum Brandenburg  Bernau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herzzentrum Brandenburg  Bernau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herzzentrum Brandenburg  Bernau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Universit\u00e4res Herzzentrum Eppendorf Hamburg  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Boekstegers","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Klinikum Siegburg (Kardiologie und Angiologie)  Siegburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Department of Cardiology Universit\u00e4tsmedizin Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdal","family":"Safak","sequence":"additional","affiliation":[{"name":"Deapartment of Cardiology and Clinical Cardiovascular Research Unit, Vivantes Klinikum im Friedrichshain und Am Urban, Berlin Germany and Rostock University Medical Center  Rostock 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