{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:35:41Z","timestamp":1785767741999,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review our experience with balloon testing prior to atrial septal defect (ASD) closure in adults with left ventricular (LV) diastolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>ASD closure in patients with LV diastolic dysfunction may precipitate LV failure. Temporary ASD occlusion has been used in this scenario but data are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 27 patients age\u2009\u2265\u200950\u2009years undergoing temporary ASD balloon occlusion between 2000 and 2018 for suspected LV diastolic dysfunction or elevated LV end\u2010diastolic pressure (LVEDP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 72\u2009years (IQR 66.7; 75.2). Atrial fibrillation was seen in 58% of patients, hypertension in 58%, and coronary artery disease in 26%; 52% were females. Median ASD size was 13\u2009mm (10; 18) and Qp\/Qs 1.8 (1.6; 2.2). Median LVEDP was 14\u2009mmHg (12; 22); pulmonary artery wedge pressure (PAWP) 12\u2009mmHg (9; 16.5) and left atrial pressure (LAP) 13.5 mmHg (8; 16.3). After a median of 5 min (3; 10) of balloon occlusion, patients with baseline LVEDP \u226515\u2009mmHg had more significant increases in LVEDP (9 [6; 12] vs. 2\u2009mmHg [0.5; 5]; <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and LAP\/PAWP (10.5 [8.3; 16.3] vs. 1.5\u2009mmHg [\u22121.5; 3]; <jats:italic>p<\/jats:italic>\u2009=\u20090.0003) than those with baseline LVEDP &lt;15\u2009mmHg. None of those with a baseline LVEDP &lt;15\u2009mmHg had a LAP\/PAWP &gt;15\u2009mmHg during balloon testing compared to 92% of patients with a baseline LVEDP \u226515\u2009mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LVEDP might be used to predict LAP post\u2010ASD closure. Comorbidities typically associated with LV diastolic dysfunction are common in these patients and should be considered in their management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28150","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T13:48:22Z","timestamp":1549979302000},"page":"1069-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Temporary balloon occlusion of atrial septal defects in suspected or documented left ventricular diastolic dysfunction: Hemodynamic and clinical findings"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-8474","authenticated-orcid":false,"given":"William R.","family":"Miranda","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester 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