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Patients typically present with insidious symptoms related to compression of adjacent structures including the esophagus, heart, airways, and cardiac vessels. Fibrosing mediastinitis is most often triggered by <jats:italic>Histoplasmosis<\/jats:italic> infection; however, antifungal and anti\u2010inflammatory therapies are largely ineffective. While structural interventions aimed at alleviating obstruction can provide significant palliation, surgical interventions are challenging with high mortality and clinical experience with percutaneous interventions is limited. Here, we will review the presentation, natural history, and treatment of fibrosing mediastinitis, placing particular emphasis on catheter\u2010based therapies.<\/jats:p>","DOI":"10.1002\/ccd.28152","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T11:43:22Z","timestamp":1550749402000},"page":"878-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Catheter based treatments for fibrosing mediastinitis"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-0169","authenticated-orcid":false,"given":"Erin A.","family":"Fender","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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