{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:50:08Z","timestamp":1771307408204,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Many women undergoing coronary angiography for chest pain have no or only minimal coronary artery disease (CAD). However, despite the lack of obstructive CAD, they still have an increased risk of major adverse cardiovascular events. Pleiotropic effects of statins may influence microvascular function, but if statins improve microvascular function in unselected chest pain patients is not well studied. This study assessed microvascular function by using the thermodilution\u2010derived test \u201cthe index of microvascular resistance\u201d (IMR) with the aim of determining the (i) IMR level in women with chest pain and non\u2010obstructive CAD and if (ii) IMR is modified by high\u2010dose statin treatment in these patients. Additional objectives were to identify the influence of statins on the health status as assessed with generic health questionnaires and on biomarkers of endothelial activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The study was a randomized, double\u2010blind, single\u2010center trial comparing 6 months of rosuvastatin treatment with placebo. In total, 66 women without obstructive CAD were included. Mean age was 52.7 years and 55.5 years in the placebo and rosuvastatin group, respectively. Microvascular function was assessed using the IMR, health status was assessed using the SF\u201036 and EQ\u20105D questionnaires, and biochemical values were assessed at baseline and 6 months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>In the placebo group IMR was 14.6 (<jats:italic>SD<\/jats:italic> 5.7) at baseline and 14.4 (<jats:italic>SD<\/jats:italic> 6.5) at follow\u2010up. In the rosuvastatin group IMR was 16.5 (<jats:italic>SD<\/jats:italic> 7.5) at baseline and 14.2 (<jats:italic>SD<\/jats:italic> 5.8) at follow\u2010up. IMR did not differ significantly between the two study groups at follow\u2010up controlled for preintervention values. C\u2010reactive protein (CRP) was comparable between the groups at baseline, while at follow\u2010up CRP was significantly lower in the rosuvastatin group compared to placebo [0.6 (\u00b10.5) mg\/L vs. 2.6 (\u00b13.0) mg\/L; <jats:italic>p<\/jats:italic>\u2009=\u20090.002]. Whereas rosuvastatin treatment for 6 months attenuated CRP levels, it did not improve microvascular function as assessed by IMR (Clinical <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/trials.gov\">Trials.gov<\/jats:ext-link> NCT 01582165, EUDRACT 2011\u2010002630\u201039.3tcAZ).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28157","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T11:44:33Z","timestamp":1550749473000},"page":"660-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Index of microvascular resistance to assess the effect of rosuvastatin on microvascular function in women with chest pain and no obstructive coronary artery disease: A double\u2010blind randomized study"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4844-7392","authenticated-orcid":false,"given":"Ole Geir","family":"Solberg","sequence":"first","affiliation":[{"name":"Department of Cardiology Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Stavem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine, University of Oslo  Oslo Norway"},{"name":"Department of Pulmonary Medicine Akershus University Hospital  L\u00f8renskog Norway"},{"name":"Department of Health Services Research Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asgrimur","family":"Ragnarsson","sequence":"additional","affiliation":[{"name":"Department of Radiology Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Otto","family":"Beitnes","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Sk\u00e5rdal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingebj\u00f8rg","family":"Seljeflot","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine, University of Oslo  Oslo Norway"},{"name":"Center for Clinical Heart Research, Department of Cardiology Oslo University Hospital, Ullev\u00e5l  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine, University of Oslo  Oslo Norway"},{"name":"K.G. 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