{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:08:50Z","timestamp":1787983730702,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"LeBonheur Children's Hospital Foundation Research Grant","award":["641026"],"award-info":[{"award-number":["641026"]}]},{"name":"Medtronic External Research Program","award":["ISR-2017-10787"],"award-info":[{"award-number":["ISR-2017-10787"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A surgical pulmonary artery band (PAB) is used to control excessive pulmonary blood flow for certain congenital heart diseases. Previous attempts have been made to develop a transcatheter, implantable pulmonary flow restrictor (PFR) without great success. We modified a microvascular plug (MVP) to be used as a PFR. The objectives of this study were to demonstrate feasibility of transcatheter implantation and retrieval of the modified MVP as a PFR, and compare PA growth while using the PFR versus PAB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      The PFR was implanted in eight newborn piglets in bilateral branch pulmonary arteries (PAs). Immediately post\u2010PFR implantation, the right ventricular systolic pressure increased from a median of 20\u201351\u2009mmHg. Transcatheter retrieval of PFR was 100% successful at 3, 6, and 9 weeks and 50% at 12\u2010weeks post\u2010implant. A left PAB was placed via thoracotomy in four other newborn piglets. Debanding was performed 6\u2010weeks later via balloon angioplasty. On follow\u2010up, the proximal left PA diameters in the PFR and the PAB groups were similar (median 8 vs. 7.1\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11); albeit the surgical band sites required repeat balloon angioplasty secondary to recurrent stenosis. By histopathology, there was grade II vessel injury in two pigs immediately post\u2010retrieval of PFR that healed by 12 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transcatheter implantation and retrieval of the MVP as a PFR is feasible. PA growth is comparable to surgical PAB, which is likely to require reinterventions. The use of the MVP as a PFR in humans has to be trialed before recommending its routine use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.28162","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T02:36:55Z","timestamp":1551667015000},"page":"1320-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Utility of the Medtronic microvascular plug\u2122 as a transcatheter implantable and explantable pulmonary artery flow restrictor in a swine model"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-9535","authenticated-orcid":false,"given":"Abdul H.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Hoskoppal","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. K. Susheel","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Bird","sequence":"additional","affiliation":[{"name":"LeBonheur Children's Hospital University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Allen","sequence":"additional","affiliation":[{"name":"LeBonheur Children's Hospital University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Lloyd","sequence":"additional","affiliation":[{"name":"LeBonheur Children's Hospital University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Knott\u2010Craig","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Rush","family":"Waller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-0852","authenticated-orcid":false,"given":"Shyam","family":"Sathanandam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,3]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"213","article-title":"The treatment of certain congenital malformations of the heart by the creation of pulmonic stenosis to reduce pulmonary hypertension and excessive pulmonary blood flow; a preliminary report","volume":"95","author":"Muller WH","year":"1952","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.988"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.03.065"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03900-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_47_17"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(85)90243-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64498-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00546-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.09.077"},{"key":"e_1_2_8_11_1","article-title":"Percutaneous bilateral pulmonary artery banding using a re\u2010expandable covered stent: Preliminary animal study","volume":"41","author":"Nakahata YTH","year":"2011","journal-title":"Kitasato Med J"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl354"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12369"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26878"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12449"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2009.02.003"},{"issue":"11","key":"e_1_2_8_17_1","first-page":"II158","article-title":"Early clinical results of the telemetric adjustable pulmonary artery banding FloWatch\u2010PAB","volume":"110","author":"Bonnet D","year":"2004","journal-title":"Circulation"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.03.065"},{"issue":"5","key":"e_1_2_8_19_1","first-page":"707","article-title":"Non\u2010surgical ventricular training before arterial switch. 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