{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:46:01Z","timestamp":1789911961942,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to assess whether the level of aortic root calcification is associated with BAV performance\/omission during transcatheter aortic valve implantation (TAVI), and to explore related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>EASE\u2010IT TF was a prospective, observational, multicenter registry of patients undergoing TF\u2010TAVI with the Edwards SAPIEN 3, with or without BAV predilation. Valvular calcification was quantified from pre\u2010procedural multi\u2010slice computed tomography images and compared between BAV and no BAV patients. Data for 178 patients (55 BAV; 123 no BAV) were analyzed. There were no significant differences between groups in terms of regional\/leaflet sector calcification volumes, maximum asymmetry between the different leaflet sectors, or total calcification scores. Overall, a greater\u2010than\u2010average leaflet calcification volume was independently predictive of \u2265mild PVL (OR: 5.116; 95% CI: 1.042\u201338.35) and the need for post\u2010dilation (OR: 3.592; 95% CI: 1.173\u201312.14). The latter effect was abated in patients with BAV (OR: 1.837; 95% CI: 0.223\u201318.00) and intensified in those without BAV (OR: 5.575; 95% CI: 1.114\u201338.74). No other BAV\u2010dependent effects of calcification on outcomes were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the majority of transfemoral valve implantations, calcification does not appear to be the main driving factor in the decision to perform\/omit BAV. Predilation may be valuable for reducing post\u2010dilation requirements in patients only with a greater degree of leaflet calcification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28164","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T21:42:43Z","timestamp":1552513363000},"page":"469-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Degree of valve calcification in patients undergoing transfemoral transcatheter aortic valve implantation with and without balloon aortic valvuloplasty: Findings from the multicenter EASE\u2010IT TF registry"],"prefix":"10.1002","volume":"94","author":[{"given":"Christian","family":"Butter","sequence":"first","affiliation":[{"name":"Department of Cardiology, Immanuel Clinic Bernau Heart Center Brandenburg and Brandenburg Medical School (MHB)  Bernau bei Berlin 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