{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:56:41Z","timestamp":1768586201810,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the safety and efficacy of percutaneous mitral valve repair for the management of functional mitral insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe FMR is present in 25\u201330% of patients with heart failure and is an independent predictor of mortality and hospitalizations in patients with both ischemic and nonischemic cardiomyopathy. MitraClip therapy has been approved for high surgical risk patients with primary mitral regurgitation. Recent studies including two randomized trials have yielded conflicting results in terms of its clinical efficacy and outcomes for FMR. A quantitative evaluation and synthesis of this information are essential in elucidating the role of MitraClip repair for FMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a literature search using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials from September 2008 to September 2018. Studies comparing percutaneous mitral valve repair using the MitraClip device against conservative therapy for the management of functional mitral regurgitation were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies with 1,174 patients in MitraClip group and 1,015 patients in medical therapy group met inclusion criteria. The 12\u2010month mortality in the MitraClip group was 18.4% compared with 25.9% in the medical therapy group (odds ratio [OR]: 0.65 [0.50, 0.86]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.002). The rate of readmission at 12\u2009months was 29.9% in the MitraClip group compared with 54.1% in the medical therapy group (OR: 040 [0.32\u20130.49]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001. The prognostic efficacy of MitraClip repair appears to be more substantial over longer follow\u2010up period over medical therapy alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the results of this meta\u2010analysis, percutaneous mitral valve repair with MitraClip appears to be superior to medical therapy for symptomatic moderate\u2010to\u2010severe functional mitral insufficiency. Further clinical research is needed to identify the ideal patient subgroups who receive maximum benefit with the MitraClip therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28203","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T06:52:15Z","timestamp":1554187935000},"page":"820-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical outcomes of percutaneous mitral valve repair with MitraClip for the management of functional mitral regurgitation"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9620-7142","authenticated-orcid":false,"given":"Konstantinos","family":"Marmagkiolis","sequence":"first","affiliation":[{"name":"Pepin Heart Institute Florida Hospital Tampa  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-2866","authenticated-orcid":false,"given":"Abdul","family":"Hakeem","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G.","family":"Ebersole","sequence":"additional","affiliation":[{"name":"Watson Clinic LLP  Lakeland Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-4579","authenticated-orcid":false,"given":"Cezar","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, MD Anderson Cancer Center University of Texas at Houston  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Ates","sequence":"additional","affiliation":[{"name":"School of Medicine Bahcesehir University  Istanbul 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