{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T16:28:28Z","timestamp":1750350508403,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mixed aortic valve disease refers to the combination of aortic regurgitation (AR) and aortic stenosis (AS). Commonly etiologies include a bicuspid aortic valve, rheumatic heart disease, and endocarditis superimposed upon a stenotic aortic valve. Treatment depends upon the severity of disease, the presence of symptoms and the size and function of the left ventricle. We present a case of a young patient that presented with new onset acute decompensated heart failure with mixed aortic valve disease that was successful treated with transcatheter aortic valve replacement (TAVR). Invasive hemodynamics at baseline and following TAVR provide an insight into the characteristic features of mixed aortic valve disease. TAVR represents a new treatment option for critically ill patients deemed high risk or nonoperable for surgical aortic valve replacement.<\/jats:p>","DOI":"10.1002\/ccd.28221","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T10:31:53Z","timestamp":1554892313000},"page":"296-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mixed aortic valve disease treated with transcatheter aortic valve replacement in a high risk patient presenting with acute decompensated heart failure"],"prefix":"10.1002","volume":"94","author":[{"given":"Leah","family":"Raj","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Southern California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anilkumar","family":"Mehra","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Southern California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-9807","authenticated-orcid":false,"given":"David M.","family":"Shavelle","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Southern California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1056\/NEJMicm1715353"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1016\/j.cpcardiol.2017.10.004"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1016\/j.ccl.2017.08.006"},{"key":"e_1_2_5_5_1","first-page":"E74","article-title":"Hemodynamic findings of severe subacute aortic regurgitation","volume":"29","author":"Lee DW","year":"2017","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_5_6_1","first-page":"148","article-title":"Diastolic pressure\u2010volume relations in the diseased heart","volume":"39","author":"Grossman W","year":"1980","journal-title":"Fed Proc"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1016\/S0002-9149(76)80015-X"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.7326\/0003-4819-87-2-223"},{"key":"e_1_2_5_9_1","first-page":"9","article-title":"Management of acute regurgitation in left\u2010sided cardiac valves","volume":"38","author":"Mokadam NA","year":"2011","journal-title":"Tex Heart Inst J"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.1136\/heartjnl-2017-312024"},{"key":"e_1_2_5_11_1","first-page":"372","article-title":"Outcomes of surgery for severe aortic regurgitation with systolic left ventricular dysfunction","volume":"26","author":"Bruno P","year":"2017","journal-title":"J Heart Valve Dis"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1007\/s11886-017-0921-3"},{"key":"e_1_2_5_13_1","first-page":"22","article-title":"Acute aortic regurgitation in the current era of percutaneous treatment: pathophysiology and hemodynamics","volume":"26","author":"Bugan B","year":"2017","journal-title":"J Heart Valve Dis"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:25:23Z","timestamp":1694327123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/ccd.28221"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28221","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2019,4,10]]},"assertion":[{"value":"2019-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}