{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:05Z","timestamp":1786977365699,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to examine in\u2010hospital gastrointestinal (GI) bleeding, its predictors and clinical outcomes, including long\u2010term outcomes, in a national cohort of patients undergoing percutaneous coronary intervention (PCI) in England and Wales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>GI bleeding remains associated with significant morbidity, mortality, and socioeconomic burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined the temporal changes in in\u2010hospital GI bleeding in a national cohort of patients undergoing PCI between 2007 and 2014 in England and Wales, its predictors and prognostic consequences. Multivariate analysis was performed to identify independent risk factors between GI bleeding and 30\u2010day mortality. Survival analysis was performed comparing patients with, and without, GI bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 480 in\u2010hospital GI bleeds in 549,298 patients (0.09%). Overall, rates of GI bleeding remained stable over time but a significant decline was observed for patients with ST segment elevation myocardial infarction (STEMI). The strongest predictors of bleeding events were STEMI\u2014odds ratio (OR) 7.28 (95% confidence interval [95% CI] 4.82\u201311.00), glycoprotein IIb\/IIIa inhibitor use OR 3.42 (95% CI 2.76\u20134.24) and use of circulatory support OR 2.65 (95% CI 1.90\u20133.71). Antiplatelets\/coagulants (clopidogrel, prasugrel, and warfarin) were not independently associated with GI bleeding. GI bleeding was independently associated with a significant increase in all\u2010cause 30\u2010day mortality (OR 2.08 [1.52\u20132.83]). Patients with in\u2010hospital GI bleed who survived to 30\u2010days had increased all\u2010cause mortality risk at 1 year compared to non\u2010bleeders (HR 1.49 [1.07\u20132.09]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In\u2010hospital GI bleeding following PCI is rare but is a clinically important event associated with increased 30\u2010day and long\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.28222","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T23:48:56Z","timestamp":1554767336000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In\u2010hospital gastrointestinal bleeding following percutaneous coronary 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