{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:18:04Z","timestamp":1785449884189,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study reports the 1\u2010year clinical outcomes of the VitaFlow\u2122 transcatheter aortic valve system in the treatment of severe aortic stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The VitaFlow\u2122 system (MicroPort\u00ae, Shanghai, China) was developed as a novel transcatheter aortic valve replacement system to mitigate or circumvent some of the challenges associated with heavily calcified valves and bicuspid valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From September 2014 to November 2017, a prospective, multicenter, single arm study was conducted in 11 centers in China. The primary end point was all cause mortality at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and ten symptomatic aortic stenosis patients (60 men, 50 women; mean age 77.73\u2009\u00b1\u20094.78\u2009years) at prohibitive or high risk for surgery were enrolled. Mean society of thoracic surgeons score was 8.84\u2009\u00b1\u20095.58%. All\u2010cause mortality was 2.7% at 1\u2010year. Major stroke, major vascular complication, coronary artery obstruction, new pacemaker implantation occurred in 2.7, 2.7, 1.8, and 19.1% at 1\u2010year follow\u2010up, respectively. No patients had moderate or severe paravalvular leak at 1\u2010year. At 1 year follow\u2010up, 97% of patients had New York heart association \u2264II. Patients with bicuspid valves had similar outcomes as those patients with tricuspid aortic valve stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 12\u2010month clinical results support the safety and efficacy of VitaFlow\u2122 in the treatment of patients with severe aortic stenosis, including patients with bicuspid aortic valve.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28226","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T05:21:28Z","timestamp":1556169688000},"page":"332-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["VitaFlow\u2122 transcatheter valve system in the treatment of severe aortic stenosis: One\u2010year results of a multicenter study"],"prefix":"10.1002","volume":"95","author":[{"given":"Daxin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-5950","authenticated-orcid":false,"given":"Yongjian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Centre for Cardiovascular Disease Fuwai Hospital  Beijing 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