{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:10:37Z","timestamp":1775149837972,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to compare the clinical impact of mild postprocedural aortic regurgitation (post\u2010AR) to that of none\u2010trivial post\u2010AR after transcatheter aortic valve implantation (TAVI) and to identify the vulnerability factors to mild post\u2010AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Moderate\u2013severe post\u2010AR, associated with increased mortality, is an important issue. However, the clinical impact of mild post\u2010AR remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analyzed data from 1,572 consecutive patients (1,026 of none\u2010trivial post\u2010AR and 546 of mild post\u2010AR) obtained from the Optimized transCathEter vAlvular Intervention (OCEAN\u2010TAVI) Japanese multicenter registry. We evaluated the 1\u2010year cumulative cardiovascular death and re\u2010hospitalization rates for heart failure (HF) after TAVI according to the degree of post\u2010AR. Kaplan\u2013Meier curves showed no significant difference between \u201cnone\u2010trivial post\u2010AR\u201d and \u201cmild post\u2010AR\u201d in terms of cardiovascular death, but a significant difference was noted in the cumulative incidence of re\u2010hospitalization for HF between the two groups (hazard ratio 1.57, 95% confidence interval 1.02\u20132.41, <jats:italic>p<\/jats:italic>\u2009=\u2009.04). In the stratified analysis, only in patients with not more than 50% of left ventricular ejection fraction (LVEF), concentric left ventricular hypertrophy (LVH), and none\u2010trivial pre\u2010procedural aortic regurgitation (pre\u2010AR), mild post\u2010AR resulted in a higher incidence of re\u2010hospitalization for HF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, the clinical impact of mild post\u2010AR compared to none\u2010trivial post\u2010AR tended to be augmented in the presence of reduced LVEF, concentric LVH, and none\u2010trivial pre\u2010AR. Pre\u2010procedure echocardiographic findings including LVEF, left ventricular geometry, and pre\u2010AR may help to judge the necessity of postdilatation in case of mild post\u2010AR just after the bioprosthesis deployment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28279","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T09:48:21Z","timestamp":1555062501000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Update on the clinical impact of mild aortic regurgitation after transcatheter aortic valve implantation: Insights from the Japanese multicenter OCEAN\u2010TAVI registry"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-4627","authenticated-orcid":false,"given":"Nobuhiro","family":"Yoshijima","sequence":"first","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine  Tokyo 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