{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:39:40Z","timestamp":1747147180781,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effect of chronic total occlusion percutaneous coronary intervention (CTO PCI) on ventricular ectopy (VE) and symptomatology during exercise testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>During exercise, the hypoxic myocardium in the CTO\u2010territory can act as a substrate for VE and could lead to anginal complaints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the EXPLORE\u2010trial, 302 ST\u2010segment elevation myocardial infarction (STEMI)\u2010patients were randomized to CTO PCI or no\u2010CTO PCI. For this sub\u2010study, we analyzed all available exercise electrocardiograms (X\u2010ECGs) at 4 months follow\u2010up on symptoms and electrocardiographic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 155 X\u2010ECGs were available, 80 in the CTO PCI group (51.6%) and 75 in the no\u2010CTO PCI group (48.4%). There were no differences regarding exercised time, achieved endurance, ST\u2010deviation nor maximum heart\u2010rate. The percentage of patients experiencing chest\u2010pain during exercise was lower in the CTO PCI group (0% vs. 8.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.03). Also, there was a trend towards a higher maximum systolic blood pressure (SBP, 185\u2009mmHg vs. 175, <jats:italic>p<\/jats:italic>\u2009=\u2009.09). No difference in VE was found between randomization groups, but patients with successful CTO PCI had a higher frequency of VE, compared to failed and no\u2010CTO PCI (26% vs. 8%, <jats:italic>p<\/jats:italic>\u2009=\u2009.02). This did not result in higher frequencies of sustained ventricular arrhythmias or mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, in STEMI\u2010patients, CTO PCI is associated with a small reduction of chest\u2010pain during exercise and tended to be associated with an increase of maximum SBP. The observation that successful CTO PCI was associated with more VE during exercise, compared with failed\/no\u2010CTO PCI needs further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28282","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T05:07:35Z","timestamp":1554872855000},"page":"536-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exercise testing after chronic total coronary occlusion revascularization in patients with STEMI and a concurrent CTO: A subanalysis of the EXPLORE\u2010trial"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3638-3261","authenticated-orcid":false,"given":"Anna","family":"van Veelen","sequence":"first","affiliation":[{"name":"Department of Cardiology Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-4038","authenticated-orcid":false,"given":"Ivo M.","family":"van Dongen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center  The Netherlands"},{"name":"Department of Cardiology OLVG Hospital  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00eblle","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Truls","family":"R\u00e5munddal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlend","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 J.","family":"van der Schaaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology OLVG Hospital  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bimmer E. P. M.","family":"Claessen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center  The Netherlands"},{"name":"Department of Cardiology Mount Sinai Hospital  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter G.","family":"Postema","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 P. S.","family":"Henriques","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.08.024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0369-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.744"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312698"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy220"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew188"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.653568"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2018.07.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.6.2286"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm355"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.1997.tb00325.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.12.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.04.023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.61.1.143"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.64.590"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.04072.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2016.04.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc37t1.094853"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000125628.57672.CF"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000124934.84048.DF"},{"key":"e_1_2_7_23_1","article-title":"Evaluation of the impact of a chronic Total coronary occlusion on ventricular arrhythmias and long\u2010term mortality in patients with ischemic cardiomyopathy and an implantable Cardioverter\u2010defibrillator (the eCTOpy\u2010in\u2010ICD study)","volume":"7","author":"Dongen IM","year":"2018","journal-title":"J am Heart Assoc"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T17:15:15Z","timestamp":1694193315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,9]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/ccd.28282"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28282","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2019,4,9]]},"assertion":[{"value":"2019-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}