{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:24:26Z","timestamp":1793399066343,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ULISSE registry has demonstrated the real\u2010world performance of the Ultimaster biodegradable polymer sirolimus\u2010eluting stent (BP\u2010SES) in a large cohort of patients undergoing percutaneous coronary intervention, including a large proportion of patients presenting with acute myocardial infarction (AMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a subgroup analysis of the ULISSE registry in AMI patients and compared the outcomes of this vulnerable cohort with that of patients presenting without AMI (non\u2010AMI). The primary end point was the incidence of 1\u2010year target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (TV\u2010MI), and clinically indicated target lesion revascularization (TLR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,660 patients included in the ULISSE registry, 381(23%) presented with AMI, 207(54.3%) non\u2010ST elevation myocardial infarction, and 174(45.7%) ST\u2010elevation myocardial infarction. Compared with non\u2010AMI patients, those with AMI were more frequently female and smokers, with lower left ventricular ejection fraction (LVEF) and chronic kidney disease requiring dialysis. At 1 year, TLF rate was significantly higher in AMI than non\u2010AMI patients (7.9 vs. 4.1%; HR 1.98, CI 95% 1.22\u20133.23; <jats:italic>p<\/jats:italic> =\u2009.005) driven by higher rate of cardiac death (4.0 vs. 1.1%; HR 3.59, CI 95% 1.64\u20137.88; <jats:italic>p<\/jats:italic> =\u2009.01) and TV\u2010MI (2.8 vs 0.9%; HR 2.99,CI 95% 1.22\u20137.37; <jats:italic>p<\/jats:italic> =\u2009.01), without differences in TLR rate (4.3 vs. 2.9%,HR 0.66, CI95% 0.35\u20131.25; <jats:italic>p<\/jats:italic> =\u2009.2). At multivariate Cox regression analysis, eGFR &lt;40\u2009mL\/min (HR: 2.868) and LVEF &lt;40% (HR: 2.394) were the only independent predictors of TLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In AMI patients, Ultimaster BP\u2010SES implantation was associated with higher rate of TLF and definite stent thrombosis compared with non\u2010AMI patients. The high incidence of adverse events was mainly driven by the unfavorable baseline risk profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28305","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T02:01:37Z","timestamp":1556676097000},"page":"972-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["One\u2010year clinical outcome of biodegradable polymer sirolimus\u2010eluting stent in patients presenting with acute myocardial infarction: Insight from the ULISSE registry"],"prefix":"10.1002","volume":"94","author":[{"given":"Elisabetta","family":"Moscarella","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences University of Campania  Caserta Italy"},{"name":"Cardiology Unit, Ospedale \u201cSant'Anna e San Sebastiano\u201d  Caserta 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