{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:37:11Z","timestamp":1788449831728,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to determine the prevalence of peripheral artery disease (PAD) and its association with in\u2010hospital outcomes after endovascular transcatheter aortic valve replacement (EV\u2010TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>TAVR is an established treatment for patients at prohibitive, high, or intermediate surgical risk. PAD is a significant comorbidity in the determination of surgical risk. However, data on association of PAD with outcomes after EV\u2010TAVR are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients in the National Inpatient Sample who underwent EV\u2010TAVR between January 1, 2012 and September 30, 2015 were evaluated. The primary outcome was in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 51,685 patients underwent EV\u2010TAVR during the study period. Of these, 12,740 (24.6%) had a coexisting diagnosis of PAD. The adjusted odds for in\u2010hospital mortality [OR 1.08 (95% CI 0.83\u20131.41)], permanent pacemaker implantation [OR 0.98 (0.85\u20131.14)], conversion to open aortic valve replacement [OR 1.05 (0.49\u20132.26)], or acute myocardial infarction [OR 1.31(0.99\u20131.71)] were not different in patients with versus without PAD. However, patients with PAD had greater adjusted odds of vascular complications [OR 1.80 (1.50\u20132.16)], major bleeding [OR 1.20 (1.09\u20131.34)], acute kidney injury (AKI) [OR 1.19 (1.05\u20131.36)], cardiac complications [aOR 1.21 (1.01\u20131.44)], and stroke [OR 1.39(1.10\u20131.75)] compared with patients without PAD. Length of stay (LOS) was significantly longer for patients with PAD [7.23 (0.14) days vs. 7.11 (0.1) days, <jats:italic>p<\/jats:italic> &lt; 0.001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Of patients undergoing EV\u2010TAVR, ~25% have coexisting PAD. PAD was not associated with increased risk of in\u2010hospital mortality but was associated with higher risk of vascular complications, major bleeding, AKI, stroke, cardiac complications, and longer LOS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28310","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T06:39:10Z","timestamp":1556260750000},"page":"249-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of peripheral artery disease with in\u2010hospital outcomes after endovascular transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-2949","authenticated-orcid":false,"given":"Divyanshu","family":"Mohananey","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Henry Ford Health System  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanush","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Ranka","sequence":"additional","affiliation":[{"name":"Department of Medicine John H. Stroger, Jr. Hospital of Cook County  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmanmoh","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwole","family":"Adegbala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Englewood Hospital and Medical Center, Seton Hall University\u2010Hackensack Meridian School of Medicine  South Orange New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8234","authenticated-orcid":false,"given":"Tomo","family":"Ando","sequence":"additional","affiliation":[{"name":"Division of Cardiology Wayne State University\/Detroit Medical Center  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5784-9924","authenticated-orcid":false,"given":"Dee Dee","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Henry Ford Health System  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Wiley","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-6504","authenticated-orcid":false,"given":"Marvin","family":"Eng","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Henry Ford Health System  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Ramakrishna","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic  Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita","family":"Shah","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Henry Ford Health System  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Saucedo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart &amp; Vascular Center Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.03.290"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.03.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X17697832"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005456"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.006179"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.040"},{"issue":"4","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1681\/ASN.V114778","article-title":"Calcification of the aortic valve in the dialyzed patient","volume":"11","author":"London GM","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.09.047"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I6A110"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005477"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.04.034"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62590-1"},{"issue":"24","key":"e_1_2_8_17_1","first-page":"1494","article-title":"Medical management of peripheral artery disease in diabetes mellitus","volume":"36","author":"Gutierrez A","year":"2015","journal-title":"Eur Heart J"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27207"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28310","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:25:31Z","timestamp":1694327131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,25]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/ccd.28310"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28310","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,25]]},"assertion":[{"value":"2019-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}