{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:11:47Z","timestamp":1768014707126,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["Grant K23 HL141448\u201001."],"award-info":[{"award-number":["Grant K23 HL141448\u201001."]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between elevated ventricular\u2010end diastolic pressures (VEDP) and pulmonary artery wedge pressure (PAWP) on long\u2010term survival in adult Fontan patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of ventricular filling pressures on long\u2010term survival in adults post\u2010Fontan palliation is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 148 adult Fontan patients (age\u2009\u2265\u200918\u2009years) without atrioventricular valve prosthesis or pulmonary vein stenosis undergoing arterial and venous catheterization between December 1999 and November 2017. VEDP was defined as \u226512\u2009mmHg and PAWP as &gt;12\u2009mmHg based on optimal cut\u2010offs for prediction of mortality on receiver\u2010operator curves (AUC 0.63 and 0.66, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 31.3\u2009\u00b1\u20099.2 years and 48.6% of patients were females. Most common congenital defects were tricuspid atresia (36.4%) and double\u2010inlet left ventricle (28.3%); 59.5% patients had atriopulmonary Fontan connections. Mean VEDP was 11.5\u2009\u00b1\u20094.7 mmHg and PAWP 10.6\u2009\u00b1\u20094.5 mmHg (correlation coefficient .76). During a follow\u2010up of 6.0\u2009\u00b1\u20094.8 years (median 5.4, IQR 1.4\u20139.4), there were 45 deaths (30.4%). Overall survival was lower in patients with VEDP\u2009\u2265\u200912 compared to those with VEDP\u2009&lt;\u200912\u2009mmHg (<jats:italic>p<\/jats:italic>\u2009=\u2009.02). Similarly, survival was lower in patients with PAWP&gt;12 compared to patients with PAWP\u2009\u2264\u200912\u2009mmHg (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). In the multivariate model, PAWP was an independent predictor of death (HR 1.1 per mmHg, 95% CI 1.02\u20131.15, <jats:italic>p<\/jats:italic>\u2009=\u2009.009) whereas VEDP was not (HR 1.1 per mmHg, 95% CI 1.0\u20131.13; <jats:italic>p<\/jats:italic>\u2009=\u2009.08).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PAWP but not VEDP was independently associated with long\u2010term overall mortality in adult Fontan patients. Perhaps PAWP rather than VEDP should be used in the risk stratification of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28340","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T12:40:25Z","timestamp":1559220025000},"page":"803-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elevated ventricular filling pressures and long\u2010term survival in adults post\u2010Fontan"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-8474","authenticated-orcid":false,"given":"William R.","family":"Miranda","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-3294","authenticated-orcid":false,"given":"Donald J.","family":"Hagler","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine\/Division of Pediatric Cardiology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-8207","authenticated-orcid":false,"given":"Nathaniel W.","family":"Taggart","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine\/Division of Pediatric Cardiology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander C.","family":"Egbe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic  Rochester 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