{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:23:12Z","timestamp":1780546992189,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the impact of intensively lowered low\u2010density lipoprotein cholesterol (LDL\u2010C) level on the deferred lesion prognosis after revascularization deferral based on fractional flow reserve (FFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Lowering LDL\u2010C is associated with lower cardiovascular event rate, but its benefit on the deferred lesion prognosis has not been well evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, single\u2010center, observational study analyzed 192 deferred lesions with FFR value &gt;0.80 in 192 patients with stable coronary artery disease. According to the first follow\u2010up LDL\u2010C level, they were assigned to the LOW group (&lt;70\u2009mg\/dL) or the HIGH group (\u226570\u2009mg\/dL). Deferred lesion failure (DLF) was defined as the composite of deferred lesion revascularization and deferred vessel myocardial infarction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all participants, 61 and 131 patients were assigned to the LOW and the HIGH group, respectively. During the median follow\u2010up of 2.8 years, DLF occurred in 1 and 14 patients in the LOW group and the HIGH group (1.6% and 10.7%, log\u2010rank <jats:italic>p<\/jats:italic> = .043), respectively. The incidence of any unplanned revascularization was also significantly lower in the LOW group than in the HIGH group (3.3% vs. 14.5%, log\u2010rank <jats:italic>p<\/jats:italic> = .032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of DLF was significantly lower in the patients with LDL\u2010C\u2009&lt;\u200970\u2009mg\/dL than in those with LDL\u2010C\u2009\u2265\u200970\u2009mg\/dL at the first follow\u2010up after FFR\u2010based deferral of revascularization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28345","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T11:00:46Z","timestamp":1559127646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of intensively lowered low\u2010density lipoprotein cholesterol on deferred lesion prognosis"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0034-0000","authenticated-orcid":false,"given":"Shun","family":"Nakamura","sequence":"first","affiliation":[{"name":"JA Toride Medical Center  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"JA Toride Medical Center  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Teng","sequence":"additional","affiliation":[{"name":"JA Toride Medical Center  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawa","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"JA Toride Medical Center  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Kasano","sequence":"additional","affiliation":[{"name":"JA Toride Medical Center  Ibaraki 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