{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T04:26:47Z","timestamp":1752985607307,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Aim of this study is to elucidate the impact of pulmonary hypertension on patients treated with a transapical aortic valve replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with aortic stenosis (AS) the coexistence of pulmonary hypertension (PH) is associated with increased peri\u2010operative risk for surgical aortic valve replacement. For transcatheter aortic valve replacement (TAVR), it is unknown whether transapical TAVR (TA\u2010TAVR) is associated with increased peri\u2010interventional risk in PH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single center analysis in 189 patients with severe AS with (AS\u2009+\u2009PH) or without PH (AS\u2009\u2212\u2009PH) undergoing TA\u2010TAVR. PH was defined by mean pulmonary artery pressure \u226525\u2009mmHg assessed by right heart catheterization (exclusion of 64 patients due to missing results). As the primary endpoint a combination of 30\u2010day mortality or cardiopulmonary resuscitation (CPR) was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy three patients (58.4%) had PH. Increased peri\u2010interventional risk in AS\u2009+ PH patients was reflected by an increased rate of the primary endpoint in comparison to AS\u2009\u2212\u2009PH patients (24.7 vs. 3.8%; <jats:italic>p<\/jats:italic> = .002). A higher proportion of acute kidney injury (34.2 vs. 15.7%; <jats:italic>p<\/jats:italic> = .025) was found in AS\u2009+\u2009PH patients while AS\u2009\u2212\u2009PH patients showed a higher rate of bleeding in comparison AS\u2009+\u2009PH patients (18.5 vs. 6.8% <jats:italic>p<\/jats:italic> = .050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with AS\u2009+\u2009PH treated by TA\u2010TAVR are at increased peri\u2010interventional risk for severe complications in comparison to AS\u2009\u2212\u2009PH patients. Therefore, the identification of preventive therapeutic strategies is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Classifications<\/jats:title><jats:p>TAVR, transapical, pulmonary hypertension, aortic stenosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28358","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T04:05:09Z","timestamp":1559707509000},"page":"1001-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patients with severe aortic stenosis and coexisting pulmonary hypertension treated by transapical transcatheter aortic valve replacement\u2014Is there a need for increased attention?"],"prefix":"10.1002","volume":"95","author":[{"given":"Stefanie","family":"Keymel","sequence":"first","affiliation":[{"name":"Department of Cardiology, Pneumology and Angiology Medical Faculty, University Hospital Dusseldorf  Dusseldorf 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Cardiology, Pneumology and Angiology Medical Faculty, University Hospital Dusseldorf  Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shazia","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pneumology and Angiology Medical Faculty, University Hospital Dusseldorf  Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pneumology and Angiology Medical Faculty, University Hospital Dusseldorf  Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-3051","authenticated-orcid":false,"given":"Ralf","family":"Westenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pneumology and Angiology Medical Faculty, University Hospital Dusseldorf  Dusseldorf 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