{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:21:26Z","timestamp":1780716086631,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008877","name":"Biosensors International Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the impact of ticagrelor monotherapy following 1\u2010month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for bifurcation lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GLOBAL LEADERS was a randomized, superiority, all\u2010comers trial comparing 1\u2010month DAPT with ticagrelor and aspirin followed by 23\u2010month ticagrelor monotherapy (experimental treatment) with standard 12\u2010month DAPT followed by 12\u2010month aspirin monotherapy (reference treatment) in patients treated with a biolimus A9\u2010eluting stent. The primary endpoint was a composite of all\u2010cause death or new Q\u2010wave myocardial infarction (MI) at 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 15,845 patients included in this subgroup analysis, 2,498 patients (15.8%) underwent PCI for at least one bifurcation lesion. The incidence of the primary endpoint was similar between the bifurcation and nonbifurcation groups (4.7 vs. 4.0%, <jats:italic>p<\/jats:italic> = .083). The experimental treatment had no significant effect on the primary endpoint according to the presence\/absence of a bifurcation lesion (bifurcation: hazard ratio [HR]: 0.74, 95% confidence interval [CI]: 0.51\u20131.07; nonbifurcation: HR: 0.90, 95% CI: 0.76\u20131.07, <jats:italic>p<\/jats:italic> for interaction = .343), but was associated with significant reduction in definite or probable stent thrombosis (<jats:italic>p<\/jats:italic> for interaction = .022) and significant excess of stroke (<jats:italic>p<\/jats:italic> for interaction = .018) when compared with the reference treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After PCI for bifurcation lesions using 1\u2010month of DAPT followed by ticagrelor monotherapy for 23\u2009months did not demonstrate explicit benefit regarding all\u2010cause death or new Q\u2010wave MI as in the overall trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28428","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T05:35:10Z","timestamp":1565760910000},"page":"100-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical relevance of ticagrelor monotherapy following 1\u2010month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial"],"prefix":"10.1002","volume":"96","author":[{"given":"Norihiro","family":"Kogame","sequence":"first","affiliation":[{"name":"Department of Cardiology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Cardiology Toho University medical center Ohashi hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ply","family":"Chichareon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Faculty of Medicine, Division of Cardiology, Department of Internal Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"De Wilder","sequence":"additional","affiliation":[{"name":"Heart Centre Imelda Hospital Bonheiden  Bonheiden Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Modolo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Cardiology Division, Department of Internal Medicine University of Campinas (UNICAMP)  Campinas 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