{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:44:47Z","timestamp":1772131487905,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the association between current leukemia diagnosis and in\u2010hospital clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Leukemia is the most common hematological malignancy and is associated with an increased risk of thrombotic and bleeding complications in patients undergoing PCI. There are limited data around clinical outcomes of leukemia patients undergoing PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the National Inpatient Sample to investigate the outcomes of leukemia patients undergoing PCI between 2004 and 2014. Patients were then subdivided into diagnoses of acute myeloid leukemia (AML) or chronic myeloid leukemia and acute lymphoid leukemia or chronic lymphoid leukemia (CLL). Multiple logistic regressions were used to study the association of a leukemia diagnosis with in\u2010hospital outcomes: mortality, bleeding, vascular and cardiac complications, and stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 6,561,445 records of patients who underwent PCI during the study time, of which 15,789 patients had a diagnosis of leukemia. The most common leukemia subtype was CLL accounting for 75% of the cohort (<jats:italic>n<\/jats:italic> = 10,800). After multivariable adjustment, a leukemia diagnosis was associated with significantly increased odds of in\u2010hospital mortality (odds ratio [OR]: 1.41; 95% confidence interval [CI]: [1.11\u20131.79]) and bleeding (OR: 1.87; 95% CI: [1.56\u20132.09]), whereas patients with AML had a fivefold increase of in\u2010hospital mortality (OR: 5.38; 95% CI: [2.94\u20139.76]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with current diagnosis of leukemia are at increased risk of procedure\u2010related complications following PCI. A multidisciplinary approach is needed among interventional cardiologists, oncologists, and hematologists to minimize procedural complications and improve outcomes in this high\u2010risk cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28432","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T05:35:23Z","timestamp":1565760923000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Percutaneous coronary intervention and in\u2010hospital outcomes in patients with leukemia: a nationwide analysis"],"prefix":"10.1002","volume":"96","author":[{"given":"Jessica","family":"Potts","sequence":"first","affiliation":[{"name":"Keele Cardiovascular Group, Centre for Prognosis Research Institute for Primary Care and Health Sciences, Keele University  Keele UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-5222","authenticated-orcid":false,"given":"Mohamed O.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Group, Centre for Prognosis Research Institute for Primary Care and Health Sciences, Keele University  Keele UK"},{"name":"Department of Cardiology Royal Stoke University Hospital  Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Lopez Mattei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, MD Anderson Cancer Center University of Texas  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-4579","authenticated-orcid":false,"given":"Cezar A.","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, MD Anderson Cancer Center University of Texas  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Konopleva","sequence":"additional","affiliation":[{"name":"Division of Cancer Medicine, Department of Leukemia, MD Anderson Cancer Center University of Texas  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9725-1583","authenticated-orcid":false,"given":"Muhammad","family":"Rashid","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Group, Centre for Prognosis Research Institute for Primary Care and Health Sciences, Keele University  Keele UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-9429","authenticated-orcid":false,"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Group, Centre for Prognosis Research Institute for Primary Care and Health Sciences, Keele University  Keele UK"},{"name":"Cardiology, London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Group, Centre for Prognosis Research Institute for Primary Care and Health Sciences, Keele University  Keele UK"},{"name":"Department of Cardiology Royal Stoke University Hospital  Stoke\u2010on\u2010Trent UK"},{"name":"Institute of Population Health, University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Trends in Operating Room Procedures in U.S. Hospitals, 2001\u20132011: Statistical Brief #171. 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