{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:51:19Z","timestamp":1784191879096,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether age and valve size at implant contribute to outcomes after Melody transcatheter pulmonary valve replacement (TPVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Patient age and valve size at implant contribute to longevity of surgical pulmonary valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients discharged with a Melody valve in the pulmonary position, as part of three prospective Melody valve multicenter studies, comprised the study cohort. Acute and time\u2010related outcomes were analyzed according to age: children (\u226412\u2009years), adolescents (13\u201318\u2009years), young adults (19\u201329\u2009years), and older adults (\u226530\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Successful Melody valve implantation occurred in 49 children, 107 adolescents, 96 young adults, and 57 older adults. Pediatric patients (\u226418\u2009years) were more likely to have TPVR for conduit stenosis than adults (62% vs. 44%); children had the smallest conduits. After TPVR, pediatric and adult patients had similar decreases in right ventricular (RV) size by MRI, but adults had improved percentage predicted peak VO<jats:sub>2<\/jats:sub> (58% preimplant to 64% postimplant, <jats:italic>p<\/jats:italic> = .02) and FEV1 (69% pre to 71% post, <jats:italic>p<\/jats:italic> = .005). Younger age was associated with shorter freedom from RVOT dysfunction, reintervention, and explant. Children had the shortest freedom from endocarditis (<jats:italic>p<\/jats:italic> = .041), but all other groups had 5\u2010year freedom from endocarditis of \u226590%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Younger age was associated with shorter time to RVOT dysfunction, reintervention, and explant after Melody TPVR. Patients \u226513\u2009years of age were at low risk for endocarditis and explant to 5\u2009years. A better understanding of time\u2010related outcomes by age will aid in the comparison of therapeutic options for TPVR candidates.<\/jats:p><jats:p>Clinical trial registration: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00740870\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00740870<\/jats:ext-link> (NCT00740870), <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01186692\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01186692<\/jats:ext-link> (NCT01186692), and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00688571\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00688571<\/jats:ext-link> (NCT00688571).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28454","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:35:13Z","timestamp":1565958913000},"page":"607-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between patient age at implant and outcomes after transcatheter pulmonary valve replacement in the multicenter Melody valve trials"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-5075","authenticated-orcid":false,"given":"Aimee K.","family":"Armstrong","sequence":"first","affiliation":[{"name":"The Heart Center Nationwide Children's Hospital  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology Deutsches Herzzentrum Berlin  Berlin 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P.","family":"Cheatham","sequence":"additional","affiliation":[{"name":"The Heart Center Nationwide Children's Hospital  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Turner","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Carman and Ann Adams Department of Pediatrics Children's Hospital of Michigan  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-6316","authenticated-orcid":false,"given":"John F.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Medical University of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Columbia University Medical Center  New York New 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