{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:06:32Z","timestamp":1761102392563,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate mortality predictors and the role of new\u2010generation drug\u2010eluting stents (NG\u2010DES) in stent thrombosis (ST) management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>No data are available regarding the outcome of patients with ST after interventional management that includes exclusively NG\u2010DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with definite ST of DES or BMS who underwent urgent\/emergent angiography between 2015 and 2018 at our institution were considered for the study. After excluding patients who achieved TIMI\u2010flow&lt;2 after intervention or received an old\u2010generation stent, 131 patients were included. Management classification was stent or non\u2010stent treatment (medical management, thromboaspiration, balloon\u2010angioplasty). Follow\u2010up was performed to document all\u2010cause death (ACD) and target\u2010lesion\u2010revascularization (TLR) that was used for censorship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mode of presentation was STEMI in 88% and UA\/NSTEMI in 12%. Type of ST was early, late, and very late in 11, 4, and 85%, respectively. Eighty four patients received stent and 47 non\u2010stent treatment. After 926\u2009\u00b1\u200934\u2009days, 21 ACDs, 7 TLRs and no cases of definite, recurrent ST were observed. Univariate predictors of in\u2010hospital mortality were LVEF and presentation with shock or cardiac arrest. For patients discharged alive, non\u2010stent treatment (HR 4.2, <jats:italic>p<\/jats:italic> =\u2009.01), TIMI\u20102 flow (HR 7.4, <jats:italic>p<\/jats:italic> =\u2009.002) and GFR\u2009&lt;\u200960\u2009mL\/min (HR 3.8, <jats:italic>p<\/jats:italic> =\u2009.01) were independent predictors of ACD. The stent\u2010treatment group had significantly better ACD\u2010free survival after discharge, both unadjusted (<jats:italic>p<\/jats:italic> =\u2009.022) and adjusted (<jats:italic>p<\/jats:italic> =\u2009.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After ST management, different predictors were observed for in\u2010hospital mortality and mortality in patients discharged alive. The better outcome with NG\u2010DES treatment is a novel observation, warranting further studies to elucidate if it is associated with stent\u2010related or patient\u2010related factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28467","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T16:33:41Z","timestamp":1568046821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Contemporary management of stent thrombosis: Predictors of mortality and the role of new\u2010generation drug\u2010eluting stents"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-8930","authenticated-orcid":false,"given":"Athanasios","family":"Katsikis","sequence":"first","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre  Basildon UK"},{"name":"Cardiology Department General Military Hospital of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Keeble","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre  Basildon UK"},{"name":"School of Medicine Anglia Ruskin University  Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre  Basildon UK"},{"name":"School of Medicine Anglia Ruskin University  Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Jagathesan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre  Basildon UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alamgir","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre  Basildon 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University  Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigoris V.","family":"Karamasis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre  Basildon UK"},{"name":"School of Medicine Anglia Ruskin University  Chelmsford 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