{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:40:06Z","timestamp":1747147206054,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To establish the value of the SYNTAX Score\u2010II (SS\u2010II) in predicting long\u2010term mortality of patients treated with left main PCI (LM\u2010PCI) using second\u2010generation drug\u2010eluting stents (DES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The SYNTAX score (SS) and the SS\u2010II were calculated in 804 patients included in the FAILS\u20102 registry (failure in left main study with 2nd generation stents). Patients were classified in low (SS\u2010II \u226433; <jats:italic>n<\/jats:italic> = 278, 34.6%), intermediate (SS\u2010II 34\u201343; <jats:italic>n<\/jats:italic> = 260, 32.3%) and high (SS\u2010II \u226544; <jats:italic>n<\/jats:italic> = 266, 33.1%) SS\u2010II tertiles. Primary endpoint was all\u2010cause mortality. A significant difference in long\u2010term mortality was noted (5.2\u2009\u00b1\u20093.6\u2009years): 4.1, 7.5, and 16.7% in low, mid and high SS\u2010II tertiles respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). SS\u2010II score was more accurate in predicting mortality than SS (AUC = 0.73; 95%CI: 0.67\u20130.79 vs. AUC = 0.55; 95%CI: 0.48\u20130.63, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). SS\u2010II led to a reclassification in the risk of all\u2010cause mortality re\u2010allocating 73% of patients from the CABG\u2010only indication to PCI or equipoise PCI\u2010or\u2010CABG indication. Using multiple Cox regression analysis, SS\u2010II (HR: 1.07; 95%CI: 1.05\u20131.09; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), along with Acute coronary syndrome (ACS) (HR: 1.66; 95%CI: 1.03\u20132.66; <jats:italic>p<\/jats:italic> = .07) and Cardiogenic shock (CS) (HR: 2.82 (95%CI: 1.41\u20135.64; <jats:italic>p<\/jats:italic> = .003) were independent predictors of long\u2010term mortality. SS\u2010II (HR: 1.05; 95%CI: 1.04\u20131.06; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) along with Insulin dependent Type 2 DM (HR: 1.58, 95%CI: 1.09\u20132.30.; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), ACS (HR: 1.58, 95%CI: 1.16\u20132.14; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and CS (HR: 2.02 95%CI 1.16\u20133.53; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), were independent predictors of long\u2010term MACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SS\u2010II was superior to the SS in predicting outcomes associated with contemporary LM\u2010PCI. In this real\u2010world population, two clinical variables not included in the SS\u2010II, ACS and T2DM, were identified as additional markers of poor outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28468","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T05:04:56Z","timestamp":1567487096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prediction of long\u2010term patient outcome after contemporary left main stenting using the SYNTAX and SYNTAX II scores: A comparative analysis from the FAIL\u2010II multicenter registry (failure in left main study with 2nd generation stents\u2010Cardiogroup III study)"],"prefix":"10.1002","volume":"96","author":[{"given":"Enrico","family":"Cerrato","sequence":"first","affiliation":[{"name":"Interventional Cardiology Infermi Hospital, Rivoli and San Luigi Gonzaga  Orbassano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Barbero","sequence":"additional","affiliation":[{"name":"Cardiology Department \u201cSS. 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