{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:40:06Z","timestamp":1747147206711,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44HL088789"],"award-info":[{"award-number":["R44HL088789"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our pilot study investigated the association between region\u2010specific myocardial tissue temperature and tissue salvage using a novel tri\u2010lumen cooling catheter to provide rapid localized cooling directly to the heart in an open\u2010chest porcine model of ischemia\u2013reperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapeutic hypothermia remains a promising strategy to limit reperfusion injury following myocardial ischemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Large swine underwent 60\u2009min of coronary occlusion followed by 3\u2009hr of reperfusion. Prior to inducing ischemia, six temperature probes were placed directly on the heart, monitoring myocardial temperatures in different locations. Hemodynamic parameters and core temperature were also collected. Approximately 15\u2009min prior to reperfusion, the cooling catheter was inserted via femoral artery and the distal tip advanced proximal to the occluded coronary vessel under fluoroscopic guidance. Autologous blood was pulled from the animal via femoral sheath and delivered through the central lumen of the cooling catheter, delivering at 50\u2009ml\/min, 27\u00b0C at the distal tip. Cooling was continued for an additional 25\u2009min after reperfusion followed by a 5\u2010min controlled rewarming. Hearts were excised and assessed for infarct size per area at risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although cooling catheter performance was consistent throughout the study (38\u2009W), the resulting tissue cooling was not. Our results show a correlation between myocardial tissue salvage and ischemic border region (IBR) temperature at the time of reperfusion (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.59, <jats:italic>p<\/jats:italic> = 0.027). IBR tissue is the tissue located at the boundary between healthy and ischemic tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that localized, rapid, short\u2010term myocardial tissue cooling has the potential to limit reperfusion injury in humans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28480","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T09:15:45Z","timestamp":1567502145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Myocardial tissue salvage is correlated with ischemic border region temperature at reperfusion"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5246-9033","authenticated-orcid":false,"given":"Thomas L.","family":"Merrill","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Biomedical Engineering Rowan University  Glassboro New Jersey"},{"name":"Catheter Development Focal Cool, LLC  Mullica Hill New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer E.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Catheter Development Focal Cool, LLC  Mullica Hill New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise R.","family":"Merrill","sequence":"additional","affiliation":[{"name":"Catheter Development Focal Cool, LLC  Mullica Hill New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Joseph H.","family":"Gorman","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Gorman","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"issue":"13","key":"e_1_2_9_3_1","first-page":"935","article-title":"Targeting reperfusion injury in patients with ST\u2010segment elevation myocardial infarction: trials and tribulations","volume":"38","author":"Hausenloy DJ","year":"2017","journal-title":"Eur Heart J"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2016.05.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248415616187"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.226"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.080"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26139"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4002063"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1115\/1.4006853","article-title":"Improved ease of use designs for rapid heart cooling","volume":"6","author":"Merrill TL","year":"2012","journal-title":"J Med Devices"},{"key":"e_1_2_9_11_1","unstructured":"MerrillTL.Google Patents.https:\/\/www.google.com\/patents\/US8353942. 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