{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:40:09Z","timestamp":1747147209516,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this research was to assess the long\u2010term results of alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy (HOCM), with all of them receiving a standard 3\u2009mL ethanol dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Generally, ethanol (0.5\u20133 mL) is infused depending on a septal artery width or interventricular septum (IVS) thickness during alcohol septal ablation. We injected 3 mL of ethanol irrespective of IVS thickness or perforator width in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2000 and 2017, 150 HOCM patients (78 males, 72 females) underwent alcohol septal ablation procedures. In all cases we intentionally used the constant dose of ethanol (3 mL). The median of age was 52 (interquartile range: 41\u201360) years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median of follow\u2010up was 71 (interquartile range: 36\u2013110) months. Hospital mortality was 0.67% (one patient died of sepsis). Perioperative high\u2010grade atrioventricular blocks required permanent pacemaker implantations\u201418 (12%). Long\u2010term survival rates were as follows: 95.1% (95% confidence interval [CI]: 92.7\u201397.5%), 85.8% (95% CI: 83.7\u201387.0%), and 81.7% (95% CI: 79.7\u201383.7%) at 5\u2010, 10\u2010, and 15\u2010year follow\u2010up, respectively. One\u2010sample log\u2010rank test revealed no significant differences in 15\u2010year survival rates between the alcohol septal ablation cohort and age\u2010 and sex\u2010matched Russian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alcohol septal ablation with the standard (3 mL) ethanol dose is safe and efficient. Survival rates after alcohol septal ablation are comparable with those in age\u2010 and sex\u2010matched general Russian population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28499","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:11:49Z","timestamp":1569903109000},"page":"1212-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of hypertrophic obstructive cardiomyopathy patients undergoing alcohol septal ablation with a standard 3 mL dose of ethanol: Focus on long\u2010term safety"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-4817","authenticated-orcid":false,"given":"Maksim G.","family":"Kashtanov","sequence":"first","affiliation":[{"name":"Department of Endovascular therapy Sverdlovsk Regional Hospital No.1  Yekaterinburg Russia"},{"name":"Ural Federal University  Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasiya D.","family":"Rzhannikova","sequence":"additional","affiliation":[{"name":"Department of Endovascular therapy Sverdlovsk Regional Hospital No.1  Yekaterinburg Russia"},{"name":"Department of Cardiovascular surgery Ural State Medical University  Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey D.","family":"Chernyshev","sequence":"additional","affiliation":[{"name":"Department of Endovascular therapy Sverdlovsk Regional Hospital No.1  Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lev V.","family":"Kardapoltsev","sequence":"additional","affiliation":[{"name":"Department of Endovascular therapy Sverdlovsk Regional Hospital No.1  Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard M.","family":"Idov","sequence":"additional","affiliation":[{"name":"Department of Endovascular therapy Sverdlovsk Regional Hospital No.1  Yekaterinburg Russia"},{"name":"Department of Cardiovascular surgery Ural State Medical University  Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V.","family":"Berdnikov","sequence":"additional","affiliation":[{"name":"Department of Endovascular therapy Sverdlovsk Regional Hospital No.1  Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina V.","family":"Kochmasheva","sequence":"additional","affiliation":[{"name":"Department of Endovascular therapy Sverdlovsk Regional Hospital No.1  Yekaterinburg Russia"},{"name":"Department of Cardiovascular surgery Ural State Medical University  Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv693"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.073"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12SXA9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-007-0616-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.09.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-008-1083-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg052"},{"key":"e_1_2_8_9_1","unstructured":"Massachusetts General Hospital (MGH). 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