{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:23:04Z","timestamp":1771028584544,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the in\u2010hospital and short\u2010term outcome differences between males and females who underwent high\u2010risk PCI with mechanical circulatory support (MCS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Sex differences have been noted in several percutaneous coronary intervention (PCI) series with females less likely to be referred for PCI due increased risk of adverse events. However, data on sex differences in utilization and outcomes of high\u2010risk PCI with MCS is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the cVAD Registry, we identified 1,053 high\u2010risk patients who underwent PCI with MCS using Impella 2.5 or Impella CP. Patients with cardiogenic shock were excluded. A total of 792 (75.21%) males and 261 (24.79%) females were included in the analysis with median follow\u2010up of 81.5\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Females were more likely to be African American, older (72.05\u2009\u00b1\u200911.66 vs. 68.87\u2009\u00b1\u200911.17, <jats:italic>p<\/jats:italic> &lt;\u2009.001), have a higher prevalence of diabetes (59.30 vs. 49.04%, <jats:italic>p<\/jats:italic> =\u2009.005), renal insufficiency (35.41 vs. 27.39%, <jats:italic>p<\/jats:italic> =\u2009.018), and peripheral vascular disease (31.89 vs. 25.39%, <jats:italic>p<\/jats:italic> of .05). Women had a higher mean STS score (8.21\u2009\u00b1\u20098.21 vs. 5.04\u2009\u00b1\u20095.97, <jats:italic>p<\/jats:italic> &lt;\u2009.001) and lower cardiac output on presentation (3.64\u2009\u00b1\u20091.30 vs. 4.63\u2009\u00b1\u20091.49, <jats:italic>p<\/jats:italic> &lt;\u2009.001). Although women had more comorbidities, there was no difference in in\u2010hospital mortality, stroke, MI or need for recurrent revascularization compared to males. Females were more likely to have multivessel revascularization than males. Ejection fraction improved in both males and females at the time of discharge (26.59 to 31.40% and 30.75 to 36.05%, respectively, <jats:italic>p<\/jats:italic> &lt;\u2009.0001). However, females had higher rate of bleeding requiring transfusion compared with males (9.58 vs. 5.30%, <jats:italic>p<\/jats:italic> =\u2009.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Female patients undergoing high PCI were older and had more comorbidities but had similar outcomes compared to males.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28509","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T08:45:41Z","timestamp":1571647541000},"page":"536-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sex\u2010related difference in the use of percutaneous left ventricular assist device in patients undergoing complex high\u2010risk percutaneous coronary intervention: Insight from the cVAD registry"],"prefix":"10.1002","volume":"96","author":[{"given":"M Chadi","family":"Alraies","sequence":"first","affiliation":[{"name":"Wayne State University Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Kaki","sequence":"additional","affiliation":[{"name":"Department of cardiology St John Hospital and Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin","family":"Kajy","sequence":"additional","affiliation":[{"name":"Wayne State University Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimrod","family":"Blank","sequence":"additional","affiliation":[{"name":"Wayne State University Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of cardiology University of Michigan  Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wah Wah","family":"Htun","sequence":"additional","affiliation":[{"name":"Northwell Health Lenox Hill Hospital  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Glazier","sequence":"additional","affiliation":[{"name":"Wayne State University Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahir","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of cardiology St John Hospital and Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease Henry Ford Hospital  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy L.","family":"Grines","sequence":"additional","affiliation":[{"name":"Northside Hospital Cardiovascular Institute  Atlanta 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