{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:33:16Z","timestamp":1762867996975,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The United Kingdom and Ireland Implanters' registry is a multicenter registry which reports on real\u2010world experience with new transcatheter heart valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The Evolut PRO (Medtronic, Minneapolis, MN) transcatheter aortic valve is a self\u2010expanding transcatheter aortic valve with an outer pericardial wrap, designed to minimize paravalvular regurgitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between July 2017 and December 2018, clinical, procedural, and 30\u2010day outcome data were prospectively collected from all patients receiving the Evolut PRO valve across nine participating centers in the United Kingdom and Ireland. The primary efficacy outcome was the Valve Academic Research Consortium\u20102 (VARC\u20102)\u2010defined endpoint of device success. The primary safety outcome was the VARC\u20102\u2010defined composite endpoint of early safety at 30\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 317 patients underwent implantation. Mean age was 81.8\u2009\u00b1\u20096.4\u2009years and Society of Thoracic Surgeons Predicted Risk of Mortality Score 5.5\u2009\u00b1\u20091.8%. Iliofemoral access was used in 99.1% of patients. Device success was 91.2%. Mean gradient was 7.6\u2009\u00b1\u20094.7\u2009mmHg and effective orifice area 1.9\u2009\u00b1\u20090.7\u2009cm<jats:sup>2<\/jats:sup>. The incidence of moderate paravalvular regurgitation was 1.7% and there was no severe paravalvular regurgitation. A new permanent pacemaker was implanted in 17.8% of patients without a pacemaker at baseline. Early safety was demonstrated in 92.7%. At 30\u2009days, all\u2010cause mortality was 0.6%, stroke 3.8%, and major vascular complication 2.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Real\u2010world experience of the Evolut PRO transcatheter aortic valve demonstrated favorable procedural success, safety, valve function, and incidence of new permanent pacemaker implantation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28512","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T06:18:34Z","timestamp":1573539514000},"page":"1340-1346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Initial experience of a self\u2010expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-5361","authenticated-orcid":false,"given":"Cameron","family":"Dowling","sequence":"first","affiliation":[{"name":"Cardiology Clinical Academic Group St. George's, University of London and St. George's Hospital, St. George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Firoozi","sequence":"additional","affiliation":[{"name":"Cardiology Clinical Academic Group St. George's, University of London and St. George's Hospital, St. George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios","family":"Panoulas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles","family":"Dalby","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mavin N.","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tito","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Kalogeras","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamta H.","family":"Buch","sequence":"additional","affiliation":[{"name":"North West Cardiac Centre Wythenshawe Hospital, Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Levy","sequence":"additional","affiliation":[{"name":"North West Cardiac Centre Wythenshawe Hospital, Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saqib","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"North West Cardiac Centre Wythenshawe Hospital, Manchester University NHS Foundation Trust  Manchester 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Wiper","sequence":"additional","affiliation":[{"name":"Lancashire Cardiac Centre Blackpool Victoria Hospital, Blackpool Teaching Hospitals NHS Foundation Trust  Blackpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-9919","authenticated-orcid":false,"given":"Hesham K.","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Lancashire Cardiac Centre Blackpool Victoria Hospital, Blackpool Teaching Hospitals NHS Foundation Trust  Blackpool UK"},{"name":"Cardiovascular Department Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette","family":"Neylon","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Galway, Galway University Hospitals  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-2577","authenticated-orcid":false,"given":"Darren","family":"Mylotte","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Galway, Galway University Hospitals  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-6200","authenticated-orcid":false,"given":"Anthony D.","family":"Pisaniello","sequence":"additional","affiliation":[{"name":"Manchester Heart Centre Manchester Royal Infirmary, Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G. W.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Manchester Heart Centre Manchester Royal Infirmary, Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-1628","authenticated-orcid":false,"given":"Richard","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Wales, Cardiff and Vale University Health Board  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Cunnington","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Malkin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust  Leeds 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