{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:21:53Z","timestamp":1762431713913,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this meta\u2010analysis is to compare the safety and efficacy of transcatheter aortic\u2010valve replacement (TAVR) to surgical aortic valve replacement (SAVR) in low\u2010surgical\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>TAVR is proven to be safe and effective in patients with high\u2010 and intermediate\u2010risk aortic stenosis. However, there is limited data on the safety and efficacy of TAVR in patients with low surgical risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an electronic database search of all published data for studies that compared TAVR to SAVR in low\u2010surgical\u2010risk patients (mean society for thoracic surgery [STS] score &lt;4% and\/or logistic EuroScore &lt;10%) and reported on subsequent all\u2010cause mortality, cardiac mortality, stroke rates, and other outcomes of interest. Event rates were compared with a forest plot of odds ratio using a random\u2010effects model assuming interstudy heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of seven studies (<jats:italic>n<\/jats:italic> = 6,293 patients; TAVR = 2,912; and SAVR = 3,381) were included in the final analysis. There was no significant difference between TAVR and SAVR in terms of all\u2010cause mortality (OR 0.82; 95% CI 0.50\u20131.36, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> =\u200951%), cardiac mortality (OR 0.57; 95% CI 0.32\u20131.02, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> =\u20090%), new pacemaker implantation (OR = 3.11; 95% CI 0.58\u201316.60, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 89%), moderate\/severe paravalvular leak (PVL; OR 3.50; 95% CI 0.64\u201319.10, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 54%) and rate of stroke (OR 0.63; 95% CI 0.34\u20131.15, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> =\u200939%) at 1\u2010year follow\u2010up. TAVR was found to have a significantly lower incidence of atrial fibrillation (AF; OR 0.15, 95% CI 0.10\u20130.24, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> =\u200938%) as compared to SAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our meta\u2010analysis demonstrate similar rates of all\u2010cause mortality, cardiac mortality, and stroke at 1\u2010year follow\u2010up in patients undergoing TAVR and SAVR. TAVR is associated with a lower incidence of AF relative to SAVR. However, there was a significantly higher incidence of PVL with TAVR compared to SAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28520","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T09:01:50Z","timestamp":1571648510000},"page":"169-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcatheter aortic valve replacement versus surgical aortic valve replacement in low\u2010surgical\u2010risk patients: An updated meta\u2010analysis"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-1918","authenticated-orcid":false,"given":"Sunny","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi T.","family":"Pasam","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karan","family":"Wats","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jignesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srilekha","family":"Chava","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Gotesman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Frankel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Shani","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maimonides Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umesh","family":"Gidwani","sequence":"additional","affiliation":[{"name":"Department of Cardiology Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.556"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60290-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.11.008"},{"issue":"4","key":"e_1_2_8_9_1","first-page":"477","article-title":"Transcatheter aortic valve replacement for bicuspid aortic valve. 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Outcomes of transcatheter aortic valve replacement with balloon\u2010expandable Sapien3 valve in bicuspid aortic stenosis: an analysis of the STS\/TVT registry. 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