{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:27:54Z","timestamp":1753522074790,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This observational study was designed to analyze the safety and feasibility of percutaneous skin closure using a purse\u2010string suture (PSS) after MitraClip procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one consecutive patients with severe mitral regurgitation who underwent MitraClip implantation from February 2018 to January 2019 at our institution received a PSS after percutaneous mitral valve repair before withdrawal of the 24\u2010French (Fr) sheath. Protamine was not administered after venous closure at procedure end. No compression therapy (e.g., compression bandage or pneumatic compression device) was used. Patients were on bed rest for 6\u2009hrs prior to suture removal, which was accomplished 18\u201324\u2009hrs after MitraClip implantation. We analyzed the occurrence of any vascular or thromboembolic complications during the hospital stay and until the 3\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary endpoint\u2014any access\u2010related major complication\u2014did not occur in any patients. None of the patients revealed a pseudoaneurysm or an arteriovenous fistula, a thromboembolic complication, or local stenosis related to the PSS closure. The secondary endpoint\u2014 minor access\u2010site vascular complications (hematoma)\u2014 was documented in six (14.6%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Venous access\u2010site closure with a PSS without the need for protamine administration or compression therapy appears to be safe and feasible in patients undergoing MitraClip implantation with access via a 24\u2010Fr sheath.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28534","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T11:18:04Z","timestamp":1571743084000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Venous access closure using a purse\u2010string suture without heparin antagonism or additional compression after MitraClip implantation"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2731-9885","authenticated-orcid":false,"given":"Ersan","family":"Akkaya","sequence":"first","affiliation":[{"name":"Department of Cardiology and Electrophysiology Jung Stilling Hospital Siegen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korkut","family":"S\u00f6zener","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Jung Stilling Hospital Siegen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Rixe","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Jung Stilling Hospital Siegen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tsiakou","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Jung Stilling Hospital Siegen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Souretis","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Jung Stilling Hospital Siegen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Chavakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Jung Stilling Hospital Siegen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Meyners","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Jung Stilling Hospital Siegen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Tanislav","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology Jung Stilling Hospital Siegen  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