{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:23:45Z","timestamp":1770063825927,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with coronary disease may have unknown diabetes or prediabetes. We evaluated 3\u2010year outcomes after percutaneous coronary intervention (PCI) with contemporary drug\u2010eluting stents (DES) in patients with silent diabetes, prediabetes, and normoglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All BIO\u2010RESORT trial (<jats:italic>NCT01674803<\/jats:italic>) participants without known diabetes, enrolled at our center, were invited for oral glucose tolerance testing (OGTT) and measurements of fasting plasma glucose and glycated hemoglobin (HbA1c).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OGTT detected silent diabetes in 68 (6.9%), prediabetes in 132 (13.4%), and normoglycemia in 788 (79.8%) of all 988 study participants. Follow\u2010up was available in 986 (99.8%) patients. The main endpoint target vessel failure (TVF: cardiac death, target vessel\u2010related myocardial infarction [MI], or target vessel revascularization) differed between groups (14.8, 9.9, and 5.6%; <jats:italic>p<\/jats:italic> = .002), driven by MI during the first 48\u2009hr and by cardiac death (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>p<\/jats:italic> = .026). Between 48\u2009hr and 3\u2010years, there was no significant between\u2010group difference in TVF, target vessel MI, and target vessel revascularization. Multivariable analysis demonstrated that silent diabetes was independently associated with TVF (adjusted HR: 2.52, 95%\u2010CI: 1.26\u20135.03). An <jats:italic>alternative<\/jats:italic> diagnostic approach\u2014HbA1c and fasting plasma glucose\u2014detected silent diabetes and prediabetes in 33 (3.3%) and 217 (22.0%) patients, and normoglycemia in 738 (74.7%); TVF rates were 12.1, 7.9, and 6.0% (<jats:italic>p<\/jats:italic> = .23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients without known diabetes, abnormal glucose metabolism by OGTT was independently associated with higher 3\u2010year TVF rates after PCI with contemporary DES. This difference was driven by periprocedural MI and cardiac death. After the first 48\u2009hr, the rates of TVF, target vessel MI, and target vessel revascularization were low and did not differ significantly between metabolic groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28536","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T06:54:51Z","timestamp":1571381691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Three\u2010year clinical outcome in all\u2010comers with \u201csilent\u201d diabetes, prediabetes, or normoglycemia, treated with contemporary coronary drug\u2010eluting stents: From the BIO\u2010RESORT Silent Diabetes study"],"prefix":"10.1002","volume":"96","author":[{"given":"Eline H.","family":"Ploumen","sequence":"first","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS Technical Medical Centre, University of Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaly A.","family":"Buiten","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS Technical Medical Centre, University of Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies M.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine J.M.","family":"Doggen","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Services Research, Faculty BMS Technical Medical Centre, University of Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Gert","family":"van Houwelingen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"Stoel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits H.A.F.","family":"de Man","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Zocca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente  Enschede The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS Technical Medical Centre, University of Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard C.M.","family":"Linssen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Group Twente, Almelo and Hengelo  Almelo The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cees","family":"Doelman","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medlon b.v., Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert 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