{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:13:14Z","timestamp":1775819594726,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical revascularization is associated with improved ventricular function and clinical outcomes among patients with ischemic cardiomyopathy. There are less extensive data on changes in ventricular function among patients with ischemic cardiomyopathy undergoing percutaneous coronary intervention (PCI). Accordingly, we sought to assess the extent and predictors of change in left ventricular ejection fraction (\u0394LVEF) among patients undergoing hemodynamically\u2010supported PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed \u0394LVEF following hemodynamically\u2010supported PCI (with Impella or intra\u2010aortic balloon counterpulsation) among patients enrolled in the PROTECT II trial and cVAD registry. The \u0394LVEF was compared among patients with paired echocardiography at baseline and at least 30\u2009days of follow\u2010up. Independent correlates of \u0394LVEF (modeled continuously and with an absolute \u0394LVEF\u22655%) were assessed using multivariable models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 689 patients with paired echocardiographic data included in the analysis, the mean LVEF improved from 24.8\u2009\u00b1\u20099.9% to 31.4\u2009\u00b1\u200913.3% after PCI, for a net increase of 6.5\u2009\u00b1\u200910.8% (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). A total of 395 (57%) patients had \u0394LVEF\u2009\u2265\u20095% following hemodynamically\u2010supported PCI. The number of vessels treated was associated with \u0394LVEF (\u0394LVEF 5.5% with 1 vessel, 6.6% with 2 vessels, and 8.3% with 3 vessels, <jats:italic>p<\/jats:italic> for trend = .046). A lower baseline LVEF, absence of a history of congestive heart failure or aldosterone receptor antagonist use, and a greater number of vessels treated were independent correlates of LVEF improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with severe left ventricular systolic dysfunction and paired echocardiographic assessments, an improvement in LVEF was observed following hemodynamically\u2010supported PCI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28557","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T15:58:08Z","timestamp":1573055888000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improvement in left ventricular function following higher\u2010risk percutaneous coronary intervention in patients with ischemic cardiomyopathy"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-2261","authenticated-orcid":false,"given":"Juan J.","family":"Russo","sequence":"first","affiliation":[{"name":"Columbia University Medical Center  New York New York"},{"name":"University of Ottawa Heart Institute  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha","family":"Prasad","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-7485","authenticated-orcid":false,"given":"Darshan","family":"Doshi","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Karmpaliotis","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish A.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Popma","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-4341","authenticated-orcid":false,"given":"Ashish","family":"Pershad","sequence":"additional","affiliation":[{"name":"Banner \u2013 University Medical Center Phoenix  Phoenix Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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