{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T03:59:18Z","timestamp":1763179158945,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>We sought to compare clinical outcomes after percutaneous coronary intervention (PCI) in patients on versus not on hemodialysis (HD) and examine whether high on\u2010treatment platelet reactivity (HPR) further impacts outcomes among patients on HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Both chronic kidney disease (CKD) and HPR are predictors of major adverse cardiac events (MACE) after PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Two\u2010year outcomes of patients from the prospective, multicenter ADAPT\u2010DES study (<jats:italic>N<\/jats:italic> = 8,582) were analyzed according to HD status at enrollment. All patients underwent platelet function testing with the VerifyNow assay; HPR on clopidogrel was defined as P2Y12 reaction units (PRU) &gt;208.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Compared with non\u2010HD patients, patients on HD (<jats:italic>n<\/jats:italic> = 85) had significantly higher baseline PRU (median 254 vs. 188, <jats:italic>p<\/jats:italic> = .001) and more frequently had HPR (61.7% vs. 42.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). HD was associated with increased 2\u2010year rates of MACE (death, myocardial infarction (MI) or definite stent thrombosis (ST); 23.4% vs. 10.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). HD was also strongly associated with 2\u2010year overall mortality, cardiac death, MI, target vessel revascularization, major bleeding, stroke and ST. Following adjustment for HPR and other covariates, HD was independently associated with overall mortality, MI, ST, and major bleeding at 2\u2009years. The relationship between HD status and 2\u2010year MACE was consistent in patients with and without HPR (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub> = .78).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Nearly two\u2010thirds of patients on HD exhibited HPR on clopidogrel, and both HD and HPR were independently associated with 2\u2010year adverse outcomes after DES implantation. However, the deleterious impact of HD on clinical outcomes was present in both patients with and without HPR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28577","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T11:50:38Z","timestamp":1573645838000},"page":"793-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of high on\u2010treatment platelet reactivity on outcomes following PCI in patients on hemodialysis: An ADAPT\u2010DES substudy"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-0213","authenticated-orcid":false,"given":"Geoffrey A.","family":"Rubin","sequence":"first","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center  New York New York"},{"name":"Clinical Trails Center Cardiovascular Research Foundation  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Chen","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center  New York New York"},{"name":"Clinical Trails Center Cardiovascular Research Foundation  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Redfors","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center  New York New York"},{"name":"Clinical Trails Center Cardiovascular Research Foundation  New York New York"},{"name":"Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"Clinical Trails Center Cardiovascular Research Foundation  New York New York"},{"name":"Montefiore Medical Center  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Baber","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Trails Center Cardiovascular Research Foundation  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Stuckey","sequence":"additional","affiliation":[{"name":"LeBauer\u2010Brodie Center for Cardiovascular Research and Education\/Cone Health  Greensboro North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"Helios Amper\u2010Klinikum  Dachau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Sanger Heart and Vascular Institute\/Atrium Health  Charlotte North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz\u2010Josef","family":"Neumann","sequence":"additional","affiliation":[{"name":"Heart Center University of Freiburg  Bad Krozingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Christopher","family":"Metzger","sequence":"additional","affiliation":[{"name":"Ballad Health CVA Heart Institute  Kingsport Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-0533","authenticated-orcid":false,"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"The Carl and Edyth Lindner Center for Research and Education at The Christ Hospital  Cincinnati Ohio"},{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Cox","sequence":"additional","affiliation":[{"name":"CVA Brookwood Baptist Hospital  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Reid Heart Center FirstHealth of the Carolinas  Pinehurst North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce R.","family":"Brodie","sequence":"additional","affiliation":[{"name":"LeBauer\u2010Brodie Center for Cardiovascular Research and Education\/Cone Health  Greensboro North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Ernest L.","family":"Mazzaferri","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center  Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Clinical Trails Center Cardiovascular Research Foundation  New York New York"},{"name":"The Zena and Michael A. 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