{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:05Z","timestamp":1786977365797,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify clinical and procedural practice predictors of avoidable complications during transcatheter aortic valve replacement (TAVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>TAVR is evolving as a viable strategy for treatment of aortic stenosis (AS). Vascular complications, major bleeding, or pericardial tamponade may be influenced by procedural practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Oxford TAVR (OxTAVI) prospective registry was retrospectively analyzed to identify predictors of avoidable procedural complications in a contemporary cohort of transfemoral TAVR between January 2015 and September 2018. The primary endpoint was defined as a hierarchic composite of in\u2010hospital mortality, pericardial effusion\/cardiac tamponade, major bleeding, and vascular access complications. Individual components of the primary endpoint have been analyzed separately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five\u2010hundred\u2010twenty\u2010nine patients underwent transfemoral TAVR using contemporary techniques during the study period and were enrolled in the OxTAVI registry.<\/jats:p>\n                    <jats:p>\n                      Female sex and high frailty were associated with a higher risk of death, major bleeding, vascular complication or pericardial tamponade. The use of ultrasound (US) guidance for vascular access management was independently associated with a reduced composite primary endpoint (OR = 0.35, CI:0.14\u20130.86,\n                      <jats:italic>p<\/jats:italic>\n                      = .02) after adjustment for clinical confounders, largely driven by a threefold reduction in vascular access complication (OR = 0.29, CI:0.15\u20130.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Performing rapid pacing via the left ventricle guidewire (LV\u2010GW) was associated with a significant decrease in the risk of cardiac tamponade\/pericardial effusion (OR = 0.19, CI:0.05\u20130.66,\n                      <jats:italic>p<\/jats:italic>\n                      = .009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>US\u2010guided vascular access management and rapid pacing via the LV\u2010GW are important determinants of reduced procedural complications during TAVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.28578","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T13:41:02Z","timestamp":1574170862000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ultrasound guided vascular access site management and left ventricular pacing are associated with improved outcomes in contemporary transcatheter aortic valve replacement: Insights from the OxTAVI registry"],"prefix":"10.1002","volume":"96","author":[{"given":"Rafail A.","family":"Kotronias","sequence":"first","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"},{"name":"Department of Cardiovascular Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Scarsini","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"},{"name":"Department of Medicine, Division of Cardiology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni L.","family":"De Maria","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skanda","family":"Rajasundaram","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Sayeed","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Krasopoulos","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Grebenik","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Keiralla","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Newton","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Banning","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-2395","authenticated-orcid":false,"given":"Rajesh K.","family":"Kharbanda","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals, NHS Trust  Oxford 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