{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:33:08Z","timestamp":1790429588287,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014338","name":"JW and HM Goodman Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008645","name":"Terumo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to systematically investigate feasibility of radiofrequency intravascular ultrasound (RF\u2010IVUS) analysis of blood signals for assessing functionally significant coronary stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, in\u2010vivo human study was performed to evaluate 83 intermediate coronary lesions from 75 patients, using 40\u2010MHz RF\u2010IVUS, fractional flow reserve (FFR) and instantaneous wave\u2010free ratio (iFR). Average blood integrated\u2010backscatter (IB) values within lumen were measured at proximal and distal segments to the stenosis; \u0394IB values between the two sites were calculated. Second, bench\u2010test was performed to assess relationships of blood IB values to blood flow velocity and hematocrit using 40 and 60\u2010MHz RF\u2010IVUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In in\u2010vivo study, \u0394IB values across the stenosis significantly correlated with both FFR (<jats:italic>r<\/jats:italic> = \u2212.85, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) and iFR (<jats:italic>r<\/jats:italic> = \u2212.65, p\u2009&lt;\u2009.0001), which was confirmed in small minimum lumen area (MLA) lesions (MLA &lt;2.0\u2009mm<jats:sup>2<\/jats:sup>). Receiver operating characteristic curve analyses identified the best cut\u2010off value as 10.06 of \u0394IB values for predicting FFR \u22640.8 and iFR \u22640.89 (sensitivity 76.2 and 95.5%, specificity 100 and 82.0%, positive predictive value 100 and 65.6%, negative predictive value 80.4 and 98.0%, accuracy 92.9 and 92.8% for FFR and iFR). Bench\u2010test study also identified that blood IB values exponentially changed as a function of blood flow velocity at any given hematocrit in both 40 and 60\u2010MHz RF\u2010IVUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports the potential utility of RF\u2010IVUS analysis of blood signals to estimate functional ischemia, demonstrating relationships of blood \u0394IB values to FFR and iFR, as well as relationships between blood IB values and flow velocity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28612","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T13:16:54Z","timestamp":1574947014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intravascular ultrasound radiofrequency signal analysis of blood speckles: Physiological assessment of intermediate coronary artery stenosis"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7151-2167","authenticated-orcid":false,"given":"Kozo","family":"Okada","sequence":"first","affiliation":[{"name":"Division of Cardiology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hibi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-2921","authenticated-orcid":false,"given":"Kensuke","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Division of Cardiology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yagami","sequence":"additional","affiliation":[{"name":"Terumo Corporation  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Honda","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Cardiology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.077"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-019-00603-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.03.013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.12.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116727"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000457"},{"key":"e_1_2_9_9_1","first-page":"130","article-title":"Comparison between minimum lumen cross\u2010sectional area and intraluminal ultrasonic intensity analysis using integrated backscatter intravascular ultrasound for prediction of functionally significant coronary artery stenosis","volume":"6","author":"Takami H","year":"2018","journal-title":"Heart Vessels"},{"key":"e_1_2_9_10_1","first-page":"210","article-title":"Comparison between instantaneous wave\u2010free ratio versus morphometric assessments by intracoronary imaging","volume":"90","author":"Matsushita K","year":"2018","journal-title":"Heart Vessels"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-005-2647-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.07.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.12.010"},{"key":"e_1_2_9_14_1","unstructured":"MintzGS NissenSE AndersonWD BaileySR ErbelR FitzgeraldPJ PintoFJ RosenfieldK SiegelRJ TuzcuEM YockPG. American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition Measurement and Reporting of Intravascular Ultrasound Studies (IVUS). A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents2001. p.1478\u20131492."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.3.6878705"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2012.03.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90233-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.034"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28612","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:19:40Z","timestamp":1693855180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,28]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/ccd.28612"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28612","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,28]]},"assertion":[{"value":"2019-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}