{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:34:40Z","timestamp":1778099680188,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astra-Zeneca"},{"name":"French Ministry of Health","award":["PREPS 2014 14-0040"],"award-info":[{"award-number":["PREPS 2014 14-0040"]}]},{"name":"Grenoble Alpes Data Institute","award":["ANR-15-IDEX-02"],"award-info":[{"award-number":["ANR-15-IDEX-02"]}]},{"name":"MSD France"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to compare baseline characteristics, coronary angiogram findings, and in\u2010hospital outcomes between female and male patients with ST\u2010segment elevation myocardial infarction (STEMI) under the age of 45\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Although sex differences in risk factor profile have been documented for young patients with STEMI, limited data exist on the prevalence of spontaneous coronary artery dissection in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As part of an ongoing hospital\u2010based registry of suspected STEMI, we analyzed the original data for 51 women under the age of 45\u2009years matched with 93 men of similar age who underwent coronary angiography at two percutaneous coronary intervention centers, between January 2003 and December 2012. Two interventional cardiologists independently reviewed coronary angiograms for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age for all patients was 39\u2009years (range, 24\u201344) and the overall prevalence of cigarette smoking, dyslipidemia, hypertension, and diabetes mellitus were 70, 32, 13, and 4%, respectively. Young women were more likely to present with spontaneous coronary artery dissection (22 vs. 3%, <jats:italic>p<\/jats:italic> = .003) and more of them experienced reinfarction during the hospital course (15 vs. 1%, <jats:italic>p<\/jats:italic> = .01). The in\u2010hospital mortality rate was 2% for both sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Spontaneous coronary artery dissection is an important cause of myocardial infarction in young female adults, accounting for 22% (95% confidence interval, 11\u201335%) of women with STEMI under the age of 45\u2009years. The true prevalence of spontaneous coronary artery dissection might even be underestimated, because of the limited availability of advanced imaging techniques at the time of our study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28627","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T07:15:20Z","timestamp":1575616520000},"page":"1222-1230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sex differences in coronary artery lesions and in\u2010hospital outcomes for patients with ST\u2010segment elevation myocardial infarction under the age of 45"],"prefix":"10.1002","volume":"96","author":[{"given":"Estelle","family":"Vautrin","sequence":"first","affiliation":[{"name":"Department of Cardiology Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aure\u2010Elise Biguet 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